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一种用于快速检测巯基和成像活细胞中巯基还原修复和 H2O2 氧化应激循环的荧光探针。

A fluorescent probe for rapid detection of thiols and imaging of thiols reducing repair and H2O2 oxidative stress cycles in living cells.

机构信息

State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS), 457 Zhongshan Road, Dalian 116023, PR China.

出版信息

Chem Commun (Camb). 2013 Jan 14;49(4):391-3. doi: 10.1039/c2cc36839k. Epub 2012 Nov 27.

DOI:10.1039/c2cc36839k
PMID:23187935
Abstract

A diselenide containing fluorescent probe based on a fluorescein scaffold for thiols was developed. The fluorescent probe exhibited rapid response, high selectivity and reversibility. Confocal fluorescence microscopy was used to visualize the redox changes mediated by thiols and reactive oxygen species in living HeLa cells.

摘要

开发了一种基于荧光素骨架的含二硒键的荧光探针用于检测巯基。该荧光探针具有快速响应、高选择性和可逆性。共聚焦荧光显微镜用于可视化活 HeLa 细胞中由巯基和活性氧介导的氧化还原变化。

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