塞内加尔农村家庭环境中 Q 热与柯克斯体 DNA 的相关性。
The correlation of Q fever and Coxiella burnetii DNA in household environments in rural Senegal.
机构信息
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculté de Médecine, Marseille, France.
出版信息
Vector Borne Zoonotic Dis. 2013 Jan;13(1):70-2. doi: 10.1089/vbz.2012.1060. Epub 2012 Nov 30.
During 2008-2011, we tested 874 blood samples from febrile patients who had a fever >37.5°C, and 207 surface samples in households for Coxiella burnetii DNA in two rural Senegalese villages (Dielmo and Ndiop). Fisher's exact test and Spearman's correlation coefficient were used for statistical analysis. We identified four blood samples as positive for Coxiella burnetii DNA. The prevalence of Q fever in all tested samples was 0.46% in the two villages. C. burnetii DNA was also found in 7.5% of the dust samples in Ndiop, and in 0.9% in Dielmo; the prevalence in households was 22.6% in Ndiop and 2.6% in Dielmo. In Ndiop we found a weak correlation between positive environmental samples and the occurrence of the disease. Our findings show an association of environmental C. burnetii with human Q fever cases in a recently identified endemic area in rural Senegal.
在 2008 年至 2011 年期间，我们在塞内加尔的两个农村村庄（迪尔莫和恩迪奥普）测试了 874 份发热超过 37.5°C 的发热患者的血液样本和 207 份家庭表面样本，以检测考克斯氏体 DNA。Fisher 确切检验和 Spearman 相关系数用于统计分析。我们确定了四份血液样本为考克斯氏体 DNA 阳性。在两个村庄的所有测试样本中，Q 热的患病率为 0.46%。在恩迪奥普的尘埃样本中发现了 7.5%的 C. burnetii DNA，在迪尔莫的尘埃样本中发现了 0.9%；家庭中的患病率在恩迪奥普为 22.6%，在迪尔莫为 2.6%。在恩迪奥普，我们发现环境阳性样本与疾病的发生之间存在微弱的相关性。我们的研究结果表明，在塞内加尔农村的一个新确定的地方性地区，环境中的考克斯氏体与人类 Q 热病例有关。
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