Aix Marseille Université, Unité des Rickettsies, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, 13005 Marseille, France.
Am J Trop Med Hyg. 2013 Feb;88(2):339-43. doi: 10.4269/ajtmh.2012.12-0614. Epub 2012 Dec 18.
Tropheryma whipplei, the bacterium linked to Whipple's disease, is involved in acute infections and asymptomatic carriage. In rural Senegal, the prevalence of T. whipplei is generally high but is not homogeneous throughout households in the same village. We studied environmental samples collected in two Senegalese villages and conducted the survey to investigate the difference between households. Overall, the comparison between five households with very high T. whipplei prevalence and three households without any registered cases showed that the only difference was the presence of toilets in the latter (1/5 versus 3/3; P = 0.01423). Among the 1,002 environmental specimens (including domestic and synanthropic animals and dust sampled in households) tested for T. whipplei DNA, only four specimens were slightly positive. Humans are currently the predominant identified reservoir and source of T. whipplei in these populations. Limited access to toilets and exposure to human feces facilitate the fecal-oral transmission of T. whipplei.
与惠普尔病相关的弯曲菌属（Tropheryma whipplei）可引起急性感染和无症状携带。在塞内加尔农村，弯曲菌属的流行率通常较高，但在同一村庄的不同家庭中并不均匀。我们研究了在两个塞内加尔村庄采集的环境样本，并进行了一项调查，以研究家庭之间的差异。总体而言，对五个弯曲菌属流行率非常高的家庭和三个没有任何登记病例的家庭进行比较后发现，唯一的区别是后者有厕所（1/5 对 3/3；P=0.01423）。在对 1002 个环境标本（包括家庭中采集的家养和共生动物以及灰尘）进行的弯曲菌属 DNA 检测中，只有 4 个标本呈弱阳性。人类目前是这些人群中弯曲菌属的主要宿主和传染源。有限的厕所使用和接触人类粪便促进了弯曲菌属的粪-口传播。
