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贝氏柯克斯体 109 基因组序列,一株强力霉素耐药的临床分离株。

Genome sequence of Coxiella burnetii 109, a doxycycline-resistant clinical isolate.

机构信息

Aix Marseille Université, URMITE, UM63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France.

出版信息

J Bacteriol. 2012 Dec;194(24):6939. doi: 10.1128/JB.01856-12.

DOI:10.1128/JB.01856-12
PMID:23209205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3510555/
Abstract

Coxiella burnetii 109, with a 2.03-Mb genome, is a doxycycline-resistant human isolate that was isolated from the cardiac valve of a German male patient with Q fever endocarditis who died during the course of the treatment due to the bacterium's resistance to doxycycline. This new genome can be useful for future comparative genomic or Q fever studies.

摘要

贝氏柯克斯体 109 株,基因组大小为 2.03Mb,是一株强力霉素耐药的人源分离株,该菌从一位死于 Q 热心内膜炎的德国男性患者的心脏瓣膜中分离而来,其对强力霉素的耐药性是导致该患者死亡的原因之一。该新基因组可用于未来的比较基因组学或 Q 热研究。

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Genomotyping of Coxiella burnetii using microarrays reveals a conserved genomotype for hard tick isolates.利用微阵列对柯克斯体进行基因分型,揭示硬蜱分离株具有保守的基因型。
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