Alebachew Tigist, Yismaw Gizachew, Derabe Ayelegn, Sisay Zufan
Chief public health professionals (Tropical and infectious diseases) in St. Paulo's Millennium Medical Collage.
Ethiop J Health Sci. 2012 Nov;22(3):209-13.
Burns provide a suitable site for bacterial multiplication and are more persistent richer sources of infection than surgical wounds. Staphylococcus aureus is one of the most frequently isolated pathogens in both community and hospital practices. The objective of this study was to address the prevalence and antibiotic susceptibility patterns of S. aureus isolated from burn wound infections in Yekatit 12 Hospital, Addis Ababa Ethiopia.
This study was Cross-sectional, prospective study conducted from March to May 2011. Burn wound pus sample was collected by using convenient sampling method for culture and drug sensitivity tests were performed according to the WHO standards.
Out of 114 patients, bacterial infection was observed in 95(83.3%) of which, 66 (69.5%) had S. aureus infection. Overall prevalence of S. aureus isolation was 57.8%. Most of them were sensitive to vancomycin, clindamycin, Kanamycin and Erythromycin, but highly resistant to penicillin G. All isolates were found to be multi drug resistant, and one isolate was resistant to all the tested drugs.
The current study is highly important and informative for the high level of multi-drug resistant S. aureus isolates in burn patients. Finally, strict consideration for s. aureus infection and proper usage of antibiotic policy are recommended in decreasing the incidence and occurrence of multidrug resistant S. aureus infections in Yekatit 12 Hospitals.
烧伤为细菌繁殖提供了适宜场所，相较于手术伤口，烧伤处是更持久且丰富的感染源。金黄色葡萄球菌是社区和医院医疗实践中最常分离出的病原体之一。本研究的目的是探讨从埃塞俄比亚亚的斯亚贝巴耶卡蒂特12医院烧伤创面感染中分离出的金黄色葡萄球菌的患病率及抗生素敏感性模式。
本研究为横断面前瞻性研究，于2011年3月至5月进行。采用方便抽样法采集烧伤创面脓液样本进行培养，并根据世界卫生组织标准进行药敏试验。
在114例患者中，95例（83.3%）观察到细菌感染，其中66例（69.5%）有金黄色葡萄球菌感染。金黄色葡萄球菌的总体分离率为57.8%。它们中的大多数对万古霉素、克林霉素、卡那霉素和红霉素敏感，但对青霉素G高度耐药。所有分离株均被发现具有多重耐药性，且有一株对所有测试药物均耐药。
本研究对于烧伤患者中高水平的多重耐药金黄色葡萄球菌分离株具有高度重要性和参考价值。最后，建议在耶卡蒂特12医院严格关注金黄色葡萄球菌感染并合理使用抗生素政策，以降低多重耐药金黄色葡萄球菌感染的发生率和出现频率。
