Center for Craniofacial Regeneration, Columbia University Medical Center, College of Dental Medicine, 630 West 168th Street, New York, NY 10032, USA.
Nanomedicine (Lond). 2012 Nov;7(11):1771-84. doi: 10.2217/nnm.12.149.
Owing to its chemically reactive hydroxyl groups, dextran can be modified with different functional groups to form spherical, tubular and 3D network structures. The development of novel functional scaffolds for efficient controlled release and tissue regeneration has been a major research interest, and offers promising therapeutics for many diseases. Dextran-based scaffolds are naturally biodegradable and can serve as bioactive carriers for many protein biomolecules. The reconstruction of the in vitro microenvironment with proper signaling cues for large-scale tissue regenerative scaffolds has yet to be fully developed, and remains a significant challenge in regenerative medicine. This paper will describe recent advances in dextran-based polymers and scaffolds for controlled release and tissue engineering. Special attention is given to the development of dextran-based hydrogels that are precisely manipulated with desired structural properties and encapsulated with defined angiogenic growth factors for therapeutic neovascularization, as well as their potential for wound repair.
由于其具有化学反应性的羟基基团，葡聚糖可以用不同的官能团进行修饰，形成球形、管状和 3D 网络结构。新型功能支架的开发对于高效控制释放和组织再生一直是一个主要的研究兴趣，并为许多疾病提供了有前途的治疗方法。基于葡聚糖的支架是天然可生物降解的，并可用作许多蛋白质生物分子的生物活性载体。具有适当信号的体外微环境的重建对于大规模组织再生支架仍然没有完全开发，这仍然是再生医学中的一个重大挑战。本文将介绍用于控制释放和组织工程的基于葡聚糖的聚合物和支架的最新进展。特别关注的是精确控制具有所需结构特性的基于葡聚糖的水凝胶的开发，并封装具有明确的血管生成生长因子以实现治疗性新血管生成，以及它们在伤口修复方面的潜力。
