Mutti A, De Palma G, Goldoni M
Dipartimento di Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Parma, Parma, Italy.
G Ital Med Lav Ergon. 2012 Jul-Sep;34(3):251-4.
Plating industry is an important productive sector in all the national territory, because of its contribution to a high number of industrial products and crafts. In the chrome plating sector there is a specific chemical risk due to the exposure to compounds containing hexavalent Chromium [Cr(VI)]. Exhaled breath condensate (EBC) has been used to study both acute and long term exposure to Cr(VI) in chrome plating workers. Cr-EBC correlates with specific oxidative stress biomarkers. Moreover, both total Cr and its hexavalent fraction can be measured in EBC, which therefore is a promising biological fluid to assess the absorbed dose at the target organ level, the pulmonary reduction kinetics of Cr(VI) and in general its local pneumotoxic effects. EBC collection and analysis could give additional information to the traditional measures performed during biomonitoring.
电镀行业是全国重要的生产部门，因为它对大量工业产品和手工艺品都有贡献。在镀铬行业，由于接触含六价铬[Cr(VI)]的化合物，存在特定的化学风险。呼出气冷凝物（EBC）已被用于研究镀铬工人急性和长期接触Cr(VI)的情况。Cr-EBC与特定的氧化应激生物标志物相关。此外，EBC中可以测量总铬及其六价部分，因此它是一种很有前景的生物流体，可用于评估靶器官水平的吸收剂量、Cr(VI)的肺部还原动力学以及其一般的局部肺毒性作用。EBC的收集和分析可以为生物监测期间进行的传统测量提供额外信息。
