Institute of Biomedicine of Brazilian Semi-Arid (INCT-IBISAB), Department of Medicine, School of Medicine, Federal University of Ceará, Rua Cel, Nunes de Melo, 1315, CEP: 60430-270, Fortaleza, CE, Brazil.
BMC Gastroenterol. 2012 Dec 7;12:175. doi: 10.1186/1471-230X-12-175.
Patients with Crohn's disease (CD) have been shown to present dyspeptic symptoms more frequently than the general population. Some of these symptoms could be related to motility disorders to some degree. Then, we propose to investigate whether gastric emptying of solids in patients with inactive CD is delayed and to determine the relationships between gastric emptying and dyspeptic symptoms in inactive CD.
Twenty-six patients with inactive Crohn's disease, as defined by a Crohn's Disease Activity Index (CDAI) < 150, underwent a gastric emptying test by breath test using 13C octanoic acid coupled to a solid meal and answered a validated questionnaire (The Porto Alegre Dyspeptic Symptoms Questionnaire) to assess dyspeptic symptoms. Patients with scores ≥ 6 were considered to have dyspepsia. The control group was composed by 19 age- and sex-matched healthy volunteers.
Patients with CD had a significantly longer t 1/2 and t lag (p<0.05) than the controls. CD patients with dyspepsia had significantly (p<0.05) prolonged gastric emptying when compared to patients without dyspeptic symptoms. When the individual symptom patterns were analyzed, only vomiting was significantly associated with delayed gastric emptying (p<0.05). There was no difference between the subgroups of patients with respect to gender, CDAI scores, disease location, clinical behavior (obstructive/obstructive) or previous gastrointestinal surgery.
Delayed gastric emptying in inactive Crohn's disease patients seems to be associated with dyspeptic symptoms, particularly vomiting, even without any evidence of gastrointestinal obstruction.
与普通人群相比，克罗恩病（CD）患者常出现消化不良症状。这些症状在一定程度上可能与运动障碍有关。因此，我们拟研究活动期 CD 患者固体胃排空是否延迟，并确定胃排空与活动期 CD 患者消化不良症状之间的关系。
26 例 CD 活动指数（CDAI）<150 的活动期 CD 患者进行 13C 辛酸固体餐胃排空试验，并采用经过验证的问卷（阿雷格里港消化不良症状问卷）评估消化不良症状。评分≥6 分的患者被认为患有消化不良。对照组由 19 名年龄和性别匹配的健康志愿者组成。
CD 患者的 t1/2 和 t 延迟明显长于对照组（p<0.05）。与无消化不良症状的患者相比，有消化不良症状的 CD 患者的胃排空明显延长（p<0.05）。当分析个体症状模式时，只有呕吐与胃排空延迟显著相关（p<0.05）。在性别、CDAI 评分、疾病部位、临床行为（梗阻性/非梗阻性）或既往胃肠道手术方面，患者亚组之间无差异。
活动期 CD 患者胃排空延迟似乎与消化不良症状相关，尤其是呕吐，即使没有任何胃肠道梗阻的证据。
