Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2012 Dec;28(12):654-9. doi: 10.1016/j.kjms.2012.04.034. Epub 2012 Aug 1.
This study aims to explore whether certain occupations were associated with the risk of esophageal squamous cell carcinoma (ESCC) in Taiwan. In a hospital-based case-control study, we collected 326 newly diagnosed ESCC patients and 386 age-matched controls (the ratio of case patients: controls = 1:1-2). All respondents completed a questionnaire, including 33 occupations in which environments potential exposure to cancer-related hazards are present. Workers with dust and metal exposure were categorized into Groups A and B, respectively. Relative risks for ESCC were estimated by odds ratios adjusting for covariates (AOR). Compared with the controls, farmer/gardener (AOR = 2.08, 95% CI = 1.02-4.24) and workers in Group A (AOR = 2.80, 95% CI = 1.21-6.47) had significantly higher risk for developing ESCC. A tendency of increased risk was also found in workers in group B (OR = 5.72 95% CI = 2.33-14.03), but such association was not significant after adjusting for other covariates (AOR = 1.57, 95% CI = 0.54-6.61). Our results suggested that farmer/gardener and workers with exposure to dust had a significant excess risk of ESCC. This study added further evidence to the current knowledge that occupational hazards are important in the development of ESCC.
本研究旨在探讨某些职业是否与台湾地区食管鳞状细胞癌（ESCC）的风险相关。我们进行了一项基于医院的病例对照研究，共收集了 326 名新诊断的 ESCC 患者和 386 名年龄匹配的对照者（病例患者与对照者的比例为 1:1-2）。所有受访者均完成了一份问卷，其中包括 33 种可能存在与癌症相关危害的职业。有粉尘和金属暴露的工人分别归入 A 组和 B 组。采用调整协变量的比值比（AOR）估计 ESCC 的相对风险。与对照组相比，农民/园丁（AOR=2.08，95%CI=1.02-4.24）和 A 组工人（AOR=2.80，95%CI=1.21-6.47）发生 ESCC 的风险显著增加。B 组工人的风险也呈现增加趋势（OR=5.72，95%CI=2.33-14.03），但在调整其他协变量后，这种关联并不显著（AOR=1.57，95%CI=0.54-6.61）。我们的研究结果表明，农民/园丁和接触粉尘的工人患 ESCC 的风险显著增加。本研究为职业危害在 ESCC 发生发展中的重要性提供了进一步的证据。
