水痘带状疱疹疫苗及其对单纯疱疹病毒疫苗开发的影响。
Varicella zoster vaccines and their implications for development of HSV vaccines.
机构信息
Department of Pediatrics, Columbia University College of Physicians and Surgeons, NY, NY 10032, USA.
出版信息
Virology. 2013 Jan 5;435(1):29-36. doi: 10.1016/j.virol.2012.10.006.
Abstract
Live attenuated vaccines to prevent varicella and zoster have been available in the US for the past 17 years, with a resultant dramatic decrease in varicella incidence and a predicted future decrease in the incidence of zoster. The pathogenesis and immune responses to varicella zoster virus (VZV) as well as the safety and effectiveness of VZV vaccines are reviewed. The lack of sterilizing immunity provided by VZV vaccines has not prevented them from being safe and effective. Virological and pathological information concerning parallels and differences between VZV and herpes simplex virus (HSV) are highlighted. Although VZV and HSV are distinct pathogens, they appear to have similarities in target organs and immunity that provide an expectation of a high likelihood for the success of vaccination against HSV, and predicted to be similar to that of VZV.
摘要
过去 17 年来，美国已经有了预防水痘和带状疱疹的减毒活疫苗，这导致了水痘发病率的显著下降，并预计未来带状疱疹的发病率也会下降。本文综述了水痘带状疱疹病毒（VZV）的发病机制和免疫反应，以及 VZV 疫苗的安全性和有效性。VZV 疫苗未能提供杀菌性免疫，但这并没有妨碍它们的安全性和有效性。本文还强调了 VZV 和单纯疱疹病毒（HSV）之间的相似和不同之处的病毒学和病理学信息。虽然 VZV 和 HSV 是两种不同的病原体，但它们似乎在靶器官和免疫方面具有相似性，这为预防 HSV 的疫苗接种提供了很高的成功率预期，并预计与 VZV 相似。
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