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猫科动物乳腺肿瘤干细胞具有致瘤性、辐射抗性、化疗抗性和 ATM/p53 DNA 损伤通路激活缺陷。

Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway.

机构信息

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK.

出版信息

Vet J. 2013 Jun;196(3):414-23. doi: 10.1016/j.tvjl.2012.10.021. Epub 2012 Dec 7.

DOI:10.1016/j.tvjl.2012.10.021
PMID:23219486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3696732/
Abstract

Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in the NOD-SCID mouse and chick embryo models. This population of feline mammary carcinoma stem cells was resistant to chemotherapy and radiation, possibly due to aberrant activation of the ATM/p53 DNA damage pathway. Epithelial-mesenchymal transition was a feature of the invasive phenotype. These data demonstrate that cancer stem cells are a feature of mammary cancer in cats.

摘要

通过证明 CD133 的表达并利用肿瘤球体测定法，在猫乳腺癌细胞系中鉴定出了癌症干细胞。鉴定出的细胞群具有侵袭性的间质表型，表达多能性标志物，并在 NOD-SCID 小鼠和鸡胚模型中增强了肿瘤的形成。这群猫乳腺肿瘤干细胞对化疗和放疗有抗性，这可能是由于 ATM/p53 DNA 损伤途径的异常激活所致。上皮-间充质转化是侵袭表型的一个特征。这些数据表明，癌症干细胞是猫乳腺肿瘤的一个特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/f521adcb95a1/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/fedc62725f98/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/ff16f7921a14/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/10e41d40ac16/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/3f6233eb24db/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/6af5d882b8a8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/d88a92289026/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/f521adcb95a1/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/fedc62725f98/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/ff16f7921a14/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/10e41d40ac16/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/3f6233eb24db/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/6af5d882b8a8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/d88a92289026/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cdf/3696732/f521adcb95a1/gr6.jpg

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