Zhang Kui, Wang Xianmin
Department of Forensic Medicine, Zun Yi Medical College, Zun Yi 563003, PR China.
Leg Med (Tokyo). 2013 May;15(3):115-21. doi: 10.1016/j.legalmed.2012.10.007. Epub 2012 Dec 6.
Maternal smoking is detrimental to the development of fetuses and neonates. This meta-analysis was performed to measure the accumulated association of sudden infant death syndrome (SIDS) risk with both prenatal and postnatal maternal smoking. The odds ratio (OR) corresponding to the 95% confidence interval (CI) was used to assess the associations between maternal smoking and SIDS risk. The statistical heterogeneity among studies was assessed with the Q-test and I(2) statistics. The data for this meta-analysis were available from 35 case-control studies. The prenatal and postnatal maternal smoking was associated with a significantly increased risk of SIDS (OR=2.25, 95% CI=2.03-2.50 for prenatal maternal smoking analysis, and OR=1.97, 95% CI=1.77-2.19 for postnatal maternal smoking analysis, respectively) by random effects model. After stratified analyses, regardless of prenatal or postnatal smoking, heavy cigarette consumption increased the risk of SIDS and significantly elevated SIDS risk was found to be associated with co-sleeping with postnatal smoking mothers. Our results suggested that maternal smoking were associated with elevated SIDS risk, the effects were dose-dependent. In addition, SIDS risk was significantly increased in infants co-sleeping with postnatal smoking mothers.
母亲吸烟对胎儿和新生儿的发育有害。本荟萃分析旨在衡量产前和产后母亲吸烟与婴儿猝死综合征（SIDS）风险的累积关联。采用对应95%置信区间（CI）的比值比（OR）来评估母亲吸烟与SIDS风险之间的关联。通过Q检验和I²统计量评估研究之间的统计学异质性。本荟萃分析的数据来自35项病例对照研究。通过随机效应模型，产前和产后母亲吸烟与SIDS风险显著增加相关（产前母亲吸烟分析中，OR = 2.25，95% CI = 2.03 - 2.50；产后母亲吸烟分析中，OR = 1.97，95% CI = 1.77 - 2.19）。分层分析后，无论产前还是产后吸烟，大量吸烟都会增加SIDS风险，并且发现与产后吸烟母亲同睡会显著提高SIDS风险。我们的结果表明，母亲吸烟与SIDS风险升高相关，且这种影响呈剂量依赖性。此外，与产后吸烟母亲同睡的婴儿SIDS风险显著增加。
