School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China.
Fitoterapia. 2013 Jan;84:170-3. doi: 10.1016/j.fitote.2012.11.012. Epub 2012 Dec 3.
Two new cis-stilbenoids, sciryagarol I (1) and II (2) were isolated from the EtOAc extract of the tubers of Scirpus yagara, together with four known compounds. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature information. The compounds 3, 4 and 6 were isolated for the first time from this genus. Some compounds were tested for their cytotoxicity against human tumor cell lines and antimicrobial activity. Compounds 1-4 showed significant cytotoxicity against the Hela cell lines with IC(50) values ranging from 7.21 to 61.21μM. 1 and 2 exhibited some antimicrobial activity against Staphylococcus aureus and Candida albicans with uniform MICs of 79.3μl/ml for 2, and 152μl/ml for 1, respectively.
从长叶香蒲的根茎的乙酸乙酯提取物中分离得到了两个新的顺式二苯乙烯类化合物，即 sciryagarol I（1）和 II（2），此外还分离得到了四个已知化合物。通过综合分析其光谱数据并与文献信息进行比较，确定了所有化合物的结构。化合物 3、4 和 6 是首次从该属中分离得到的。对部分化合物进行了人肿瘤细胞系的细胞毒性和抗菌活性测试。化合物 1-4 对 Hela 细胞系表现出显著的细胞毒性，IC50 值范围为 7.21-61.21μM。化合物 1 和 2 对金黄色葡萄球菌和白色念珠菌具有一定的抗菌活性，MIC 均为 79.3μl/ml（化合物 2）和 152μl/ml（化合物 1）。
