Department of Gastroenterology, Chaim Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Gush Dan, Israel.
Curr Opin Gastroenterol. 2013 Mar;29(2):133-9. doi: 10.1097/MOG.0b013e32835bdc03.
Small bowel capsule endoscopy (SBCE) was introduced 13 years ago by Given Imaging (Yokneam, Israel). It has become one of the most important investigational tools of the small bowel. The capsule is swallowed with water after a 12 h fast, propelled via peristalsis through the gastrointestinal tract and excreted naturally. A nonvideo patency capsule was developed to confirm functional patency of the gastrointestinal tract.
Four additional companies have introduced competitive small bowel video capsules, some of which are Food and Drug Admistration (FDA) approved. Due to the easiness of the procedure, SBCE has become a first-line tool to detect small bowel abnormalities. The main indications for SBCE include obscure gastrointestinal bleeding, suspected Crohn's disease, small bowel tumors and practically any abnormal small bowel imaging. New indications are emerging like small bowel motility and monitoring of drug therapy and mucosal healing. The present review will describe the available capsules in the market, the procedure itself, present indications and future expectations. It will focus on the PillCam SB of Given Imaging as it is the one on which most of the literature is written.
Over the past 10 years, SBCE has become a routine, first-line investigational tool of many small bowel pathologies.
目的综述:小肠胶囊内镜(SBCE)于 13 年前由 Given Imaging(以色列约尼姆)推出,现已成为小肠最重要的检查手段之一。检查前患者需禁食 12 小时,随后将胶囊用清水吞服,胶囊在胃肠道蠕动的作用下自然前行,并随粪便排出体外。为了确认胃肠道的通畅情况,开发出了一种非视频胶囊。
最新发现:又有四家公司推出了具有竞争力的小肠视频胶囊,其中部分已获得美国食品药品监督管理局(FDA)批准。由于该检查操作简单,SBCE 已成为检测小肠异常的一线手段。SBCE 的主要适应证包括不明原因消化道出血、疑似克罗恩病、小肠肿瘤,以及任何异常的小肠影像学检查。目前新的适应证也在不断涌现,如小肠动力和药物治疗及黏膜愈合监测。本文将介绍目前市面上的各种胶囊、检查过程、适应证和未来展望,并重点介绍 Given Imaging 公司的 PillCam SB,因为该胶囊是文献中最常提及的。
总结:在过去的 10 年中,SBCE 已成为许多小肠疾病的常规一线检查手段。