在中年男性普通人群样本中，社会影响和心血管危险因素作为血浆纤维蛋白原浓度的决定因素。
Social influences and cardiovascular risk factors as determinants of plasma fibrinogen concentration in a general population sample of middle aged men.
作者信息
Rosengren A, Wilhelmsen L, Welin L, Tsipogianni A, Teger-Nilsson A C, Wedel H
机构信息
Department of Medicine, Ostra Hospital, Gothenburg University, Sweden.
出版信息
BMJ. 1990 Mar 10;300(6725):634-8. doi: 10.1136/bmj.300.6725.634.
OBJECTIVE
To analyse the relation between fibrinogen concentration and social class and other social factors found to be related to mortality. The results regarding cardiovascular disease are unpublished, as yet.
DESIGN
Cross sectional population study.
SETTING
City of Gothenburg, Sweden.
SUBJECTS
639 Men from a population sample of 1016 men aged 50 in 1983. They were all employed and had no history of myocardial infarction or stroke. Fibrinogen values were available for all of them.
MAIN OUTCOME MEASURE
Fibrinogen concentration in relation to socioeconomic state according to occupation, and other social influences determined as number of people in the household and scores of social activities and activities in and outside the house.
RESULTS
Men with low scores for activities at home had a mean plasma fibrinogen concentration of 3.34 g/l (95% confidence interval 3.21 to 3.47), whereas those with an intermediate score had a mean concentration of 3.16 (3.00 to 3.32) g/l and those with a high score 3.02 (2.95 to 3.10) g/l. Similar inverse relations were noted for the two other activity scores and for occupational class (class 1 being unskilled and semiskilled workers and class 5 professionals and executives) and the number of people in the household. Smoking exerted a strong influence on fibrinogen concentration, the relations between fibrinogen concentration and social factors being evident only in non-smokers. The mean difference in fibrinogen value between the non-smokers with the lowest activity scores at home and those with the highest scores was 0.36 (0.19 to 0.54) g/l, and similar differences were seen for the two other activity scores. Multiple regression analyses showed smoking, body mass index, the sum of all activities (inverse relation), and diabetes to be independently associated with fibrinogen value, whereas occupational class (p = 0.81) and the number of people in the household (p = 0.09) were not.
CONCLUSIONS
Psychosocial influences seem to influence the coagulation system in the body in a way that is associated with cardiovascular disease and premature death.
目的
分析纤维蛋白原浓度与社会阶层以及其他已发现与死亡率相关的社会因素之间的关系。关于心血管疾病的结果尚未发表。
设计
横断面人群研究。
地点
瑞典哥德堡市。
研究对象
从1983年年龄为50岁的1016名男性的人群样本中选取的639名男性。他们均有工作，且无心肌梗死或中风病史。所有人都有纤维蛋白原值。
主要观察指标
根据职业划分的纤维蛋白原浓度与社会经济状况的关系，以及其他社会影响因素，如家庭人口数量、社会活动得分以及室内外活动得分。
结果
在家中活动得分低的男性血浆纤维蛋白原平均浓度为3.34 g/l（95%置信区间3.21至3.47），而得分中等的男性平均浓度为3.16（3.00至3.32）g/l，得分高的男性为3.02（2.95至3.10）g/l。在其他两项活动得分、职业阶层（1类为非熟练和半熟练工人，5类为专业人员和管理人员）以及家庭人口数量方面也观察到类似的负相关关系。吸烟对纤维蛋白原浓度有强烈影响，纤维蛋白原浓度与社会因素之间的关系仅在不吸烟者中明显。家中活动得分最低的不吸烟者与得分最高的不吸烟者之间纤维蛋白原值的平均差异为0.36（0.19至0.54）g/l，其他两项活动得分也有类似差异。多元回归分析显示，吸烟、体重指数、所有活动总和（负相关关系）以及糖尿病与纤维蛋白原值独立相关，而职业阶层（p = 0.81）和家庭人口数量（p = 0.09）则无相关性。
结论
心理社会影响似乎以一种与心血管疾病和过早死亡相关的方式影响人体的凝血系统。
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