De Kozak Y, Mirshahi M
Unité de Recherche d'Optalmologie, INSERM U86, Hôtel-Dieu Institut des Cordeliers, Paris, France.
Int Ophthalmol. 1990 Jan;14(1):43-56. doi: 10.1007/BF00131168.
Experimental autoimmune uveoretinitis (EAU), a mostly T-cell dependent disease, was induced in laboratory animals by a single immunization with retinal extract or purified S-antigen in complete Freund's adjuvant. It can be prevented or suppressed by injections of either the autoantigen or monoclonal antibodies against the autoantigen. The suppression of EAU by these antibodies was associated with an anti-idiotypic antibody response. The inhibition of the pathogenic immune response by the antigen or the antibodies could be explained, according to Jerne's hypothesis of immunoregulation, by a disturbance of the network of idiotype and anti-idiotype interactions.
实验性自身免疫性葡萄膜视网膜炎（EAU）是一种主要依赖T细胞的疾病，通过在完全弗氏佐剂中用视网膜提取物或纯化的S抗原单次免疫在实验动物中诱导产生。通过注射自身抗原或针对自身抗原的单克隆抗体可以预防或抑制该病。这些抗体对EAU的抑制与抗独特型抗体反应相关。根据耶尔恩的免疫调节假说，抗原或抗体对致病性免疫反应的抑制可以通过独特型和抗独特型相互作用网络的紊乱来解释。
