Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway, Ireland.
Tissue Eng Part A. 2013 Jul;19(13-14):1491-4. doi: 10.1089/ten.TEA.2012.0721. Epub 2013 Jan 21.
Extracellular matrix (ECM)-based scaffolds, through their inherent bioactivity and molecular recognition signals, provide the ideal substrate for tissue engineering and regenerative applications. Collagen, the most abundant ECM protein, has proven itself to be a very versatile material with applications in many fields, including the leather and food industries, cosmetics, drug delivery, and tissue engineering. However, doubts persist about the optimal source of collagen for tissue engineering applications, given possible immunogenicity and disease transmission associated with animal sources and reduced bioactivity and availability of recombinant technologies. In this special edition, an attempt is made to elucidate the advantages of plant-derived human recombinant collagen and its applications in tissue engineering, particularly skin and wound healing. While results are promising, the widespread use of animal-derived collagen means that recombinant technologies may find applications in niche areas.
基于细胞外基质 (ECM) 的支架通过其固有生物活性和分子识别信号，为组织工程和再生应用提供了理想的基质。胶原蛋白是最丰富的 ECM 蛋白，已被证明是一种非常通用的材料，可应用于许多领域，包括皮革和食品工业、化妆品、药物输送和组织工程。然而，鉴于动物源胶原蛋白可能存在免疫原性和疾病传播风险，以及重组技术的生物活性和可用性降低，对于组织工程应用的最佳胶原蛋白来源仍存在疑问。在本期特刊中，尝试阐明植物来源的人类重组胶原蛋白的优势及其在组织工程，特别是皮肤和伤口愈合中的应用。虽然结果很有希望，但动物源胶原蛋白的广泛应用意味着重组技术可能会在利基领域得到应用。
