Mitchell G H, Richards W H, Voller A, Dietrich F M, Dukor P
Bull World Health Organ. 1979;57 Suppl 1(Suppl):189-97.
Vaccination of primates against malaria using antigen derived from erythrocytic parasite stages has been most successful where Freund's complete adjuvant has been employed. Since this adjuvant is clinically unacceptable its replacement is a matter of urgency.In the present work a muramyldipeptide derivative (nor-MDP) given in mineral oil has proved to be partially effective as an adjuvant for merozoite vaccination of Macaca mulatta against Plasmodium knowlesi, and saponin has proved to be effective in similar vaccination of M. fascicularis.
使用源自红细胞内寄生虫阶段的抗原对灵长类动物进行疟疾疫苗接种，在使用弗氏完全佐剂的情况下最为成功。由于这种佐剂在临床上不可接受，因此其替代迫在眉睫。在目前的工作中，已证明在矿物油中给予的一种胞壁酰二肽衍生物（去甲-MDP）作为恒河猴针对诺氏疟原虫裂殖子疫苗接种的佐剂有部分效果，并且已证明皂苷在类似的束尾猴疫苗接种中有效。
