诺-甲基二磷酸、皂苷、棒状杆菌和百日咳杆菌作为猕猴实验性疟疾疫苗接种中的免疫佐剂。
Nor-MDP, saponin, corynebacteria, and pertussis organisms as immunological adjuvants in experimental malaria vaccination of macaques.
作者信息
Mitchell G H, Richards W H, Voller A, Dietrich F M, Dukor P
出版信息
Bull World Health Organ. 1979;57 Suppl 1(Suppl):189-97.
Abstract
Vaccination of primates against malaria using antigen derived from erythrocytic parasite stages has been most successful where Freund's complete adjuvant has been employed. Since this adjuvant is clinically unacceptable its replacement is a matter of urgency.In the present work a muramyldipeptide derivative (nor-MDP) given in mineral oil has proved to be partially effective as an adjuvant for merozoite vaccination of Macaca mulatta against Plasmodium knowlesi, and saponin has proved to be effective in similar vaccination of M. fascicularis.
摘要
使用源自红细胞内寄生虫阶段的抗原对灵长类动物进行疟疾疫苗接种，在使用弗氏完全佐剂的情况下最为成功。由于这种佐剂在临床上不可接受，因此其替代迫在眉睫。在目前的工作中，已证明在矿物油中给予的一种胞壁酰二肽衍生物（去甲-MDP）作为恒河猴针对诺氏疟原虫裂殖子疫苗接种的佐剂有部分效果，并且已证明皂苷在类似的束尾猴疫苗接种中有效。
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Nor-MDP, saponin, corynebacteria, and pertussis organisms as immunological adjuvants in experimental malaria vaccination of macaques.诺-甲基二磷酸、皂苷、棒状杆菌和百日咳杆菌作为猕猴实验性疟疾疫苗接种中的免疫佐剂。
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本文引用的文献
1
Isolation of a new strain of Plasmodium knowlesi.诺氏疟原虫新菌株的分离
Nature. 1953 Jul 18;172(4368):122. doi: 10.1038/172122a0.
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Antigenic variation and protective immunity in Plasmodium knowlesi malaria.诺氏疟原虫疟疾中的抗原变异与保护性免疫
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A merozoite vaccine effective against Plasmodium knowlesi malaria.一种对诺氏疟原虫疟疾有效的裂殖子疫苗。
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Mechanisms of macrophage activation by corynebacterium parvum. II. In vivo experiments.微小棒状杆菌激活巨噬细胞的机制。II. 体内实验。
Cell Immunol. 1975 May;17(1):150-5. doi: 10.1016/s0008-8749(75)80015-3.
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Saponin adjuvants. IV. Evaluation of the adjuvant quil A in the vaccination of cattle against foot-and-mouth disease.皂苷佐剂。IV。评估Quil A佐剂在牛口蹄疫疫苗接种中的作用。
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In vitro isolation of Plasmodium knowlesi merozoites using polycarbonate sieves.使用聚碳酸酯筛网体外分离诺氏疟原虫裂殖子
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The adjuvant effect of microbial products on the immune response.微生物产物对免疫反应的佐剂作用。
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