Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia ; Drug Design and Development Research Group (DDDRG), University of Malaya, 50603 Kuala Lumpur, Malaysia.
Evid Based Complement Alternat Med. 2012;2012:473637. doi: 10.1155/2012/473637. Epub 2012 Nov 27.
Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientists worldwide to further investigate its medicinal properties. Advancement in drug design and discovery research has led to the development of synthetic drugs from B. rotunda metabolites via bioinformatics and medicinal chemistry studies. Furthermore, with the advent of genomics, transcriptomics, proteomics, and metabolomics, new insights on the biosynthetic pathways of B. rotunda metabolites can be elucidated, enabling researchers to predict the potential bioactive compounds responsible for the medicinal properties of the plant. The vast biological activities exhibited by the compounds obtained from B. rotunda warrant further investigation through studies such as drug discovery, polypharmacology, and drug delivery using nanotechnology.
宝螺蕉是姜科宝螺蕉属的一种草本植物。宝螺蕉广泛分布于亚洲国家，在那里常被用作食品成分和传统药物制剂。其传统药物用途的普及引起了全世界科学家的关注，促使他们进一步研究其药用特性。药物设计和发现研究的进展导致通过生物信息学和药物化学研究，从宝螺蕉代谢物中开发出合成药物。此外，随着基因组学、转录组学、蛋白质组学和代谢组学的出现，对宝螺蕉代谢物生物合成途径的新见解得以阐明，使研究人员能够预测负责植物药用特性的潜在生物活性化合物。从宝螺蕉中获得的化合物表现出广泛的生物活性，这使得通过药物发现、多药理学和使用纳米技术的药物传递等研究进一步研究这些化合物成为必要。
