朗格汉斯细胞的抗原呈递。
Antigen presentation by Langerhans cells.
机构信息
Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN, United States.
出版信息
Curr Opin Immunol. 2013 Feb;25(1):115-9. doi: 10.1016/j.coi.2012.11.007. Epub 2012 Dec 12.
Abstract
Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response. This review focuses on the functional outcome of antigen presentation by Langerhans cells. Special attention is given to their ability to promote CD4 T cell differentiation in a variety of inflammatory contexts and whether this subset has the capacity to cross-prime CD8 T cells.
摘要
朗格汉斯细胞和其他皮肤常驻树突状细胞（DC）是皮肤适应性免疫反应发展所必需的。利用选择性 DC 亚群缺陷的小鼠进行体内实验和利用分离的 DC 进行的体外实验表明，每个亚群对适应性反应都有独特的贡献。本综述重点介绍朗格汉斯细胞对抗原呈递的功能结果。特别关注它们在各种炎症环境中促进 CD4 T 细胞分化的能力，以及这个亚群是否有能力交叉引发 CD8 T 细胞。
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本文引用的文献
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Cross-presentation by dendritic cells.树突状细胞的交叉呈递。
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Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells.人类表皮朗格汉斯细胞通过激活皮肤固有调节性 T 细胞来维持皮肤中的免疫稳态。
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Langerhans cells require MyD88-dependent signals for Candida albicans response but not for contact hypersensitivity or migration.郎格汉斯细胞需要 MyD88 依赖性信号来响应白念珠菌，但不需要来响应接触性过敏或迁移。
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