State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Org Lett. 2013 Jan 18;15(2):314-7. doi: 10.1021/ol303226c. Epub 2012 Dec 24.
Scopariusins A-C (1-3), three novel rearranged ent-halimanoids with a bicycle[5.4.0]undecane ring system, two new normal ent-halimanoids (4 and 5), and a new ent-clerodanoid (6) were isolated from Isodon scoparius. Moreover, a biomimetic transformation from the ent-clerodanoid to the normal and the rearranged ent-halimane diterpenoids was successfully accomplished, which not only validated the biogenetic hypothesis in this plant but also confirmed the absolute configurations of 1 and 5.
从 Scoparius scoparius 中分离得到了三个新型的骨架重排的 ent-半日花烷类化合物 Scopariusins A-C（1-3），具有自行车[5.4.0]十一烷环系统，两个新的正常 ent-半日花烷类化合物（4 和 5）和一个新的 ent-克劳丹烷类化合物（6）。此外，成功地完成了从 ent-克劳丹烷到正常和重排的 ent-半日花烷二萜类化合物的仿生转化，不仅验证了该植物中的生物发生假说，还确定了 1 和 5 的绝对构型。
