State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Org Lett. 2013 Sep 6;15(17):4446-9. doi: 10.1021/ol401991u. Epub 2013 Aug 14.
Scopariusic acid (1), a new ent-clerodane-based meroditerpenoid with a unique cyclobutane ring and an unusual 1-octen-3-ol substituent, together with its biosynthetic related compound 2, were isolated from the aerial parts of Isodon scoparius. The structures of 1 and 2, including their absolute configurations, were determined by spectroscopic methods, single-crystal X-ray diffraction analysis, and chemical methods. Compound 1 showed weak cytotoxicity and moderate immunosuppressive activity.
旋覆花酸（1）是一种新的基于-ent-克氏千里光二萜类化合物，具有独特的环丁烷环和不寻常的 1-辛烯-3-醇取代基，与其生物合成相关的化合物 2 一起从旋覆花的地上部分分离得到。通过光谱方法、单晶 X 射线衍射分析和化学方法确定了 1 和 2 的结构，包括它们的绝对构型。化合物 1 表现出较弱的细胞毒性和适度的免疫抑制活性。
