School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
Eye Contact Lens. 2013 Jan;39(1):61-6. doi: 10.1097/ICL.0b013e318275e284.
Microbial adhesion to contact lenses is believed to be one of the initiating events in the formation of many corneal infiltrative events, including microbial keratitis, that occur during contact lens wear. The advent of silicone hydrogel lenses has not reduced the incidence of these events. This may partly be related to the ability of microbes to adhere to these lenses. The aim of this study was to review the published literature on microbial adhesion to contact lenses, focusing on adhesion to silicone hydrogel lenses.
The literature on microbial adhesion to contact lenses was searched, along with associated literature on adverse events that occur during contact lens wear. Particular reference was paid to the years 1995 through 2012 because this encompasses the time when the first clinical trials of silicone hydrogel lenses were reported, and their commercial availability and the publication of epidemiology studies on adverse events were studied.
In vitro studies of bacterial adhesion to unworn silicone hydrogel lens have shown that generally, bacteria adhere to these lenses in greater numbers than to the hydroxyethyl methacrylate-based soft lenses. Lens wear has different effects on microbial adhesion, and this is dependent on the type of lens and microbial species/genera that is studied. Biofilms that can be formed on any lens type tend to protect the bacteria and fungi from the effects on disinfectants. Fungal hyphae can penetrate the surface of most types of lenses. Acanthamoeba adhere in greater numbers to first-generation silicone hydrogel lenses compared with the second-generation or hydroxyethyl methacrylate-based soft lenses.
Microbial adhesion to silicone hydrogel lenses occurs and is associated with the production of corneal infiltrative events during lens wear.
微生物黏附于隐形眼镜被认为是引发许多角膜浸润性病变的起始事件之一，包括微生物角膜炎，这些病变发生在隐形眼镜佩戴期间。硅水凝胶隐形眼镜的出现并没有降低这些事件的发生率。这可能部分与微生物黏附于这些镜片的能力有关。本研究旨在回顾关于微生物黏附于隐形眼镜的已发表文献，重点关注黏附于硅水凝胶镜片的情况。
检索了关于微生物黏附于隐形眼镜的文献，以及与隐形眼镜佩戴过程中发生的不良事件相关的文献。特别参考了 1995 年至 2012 年的文献，因为这涵盖了首次报道硅水凝胶隐形眼镜临床试验以及其商业可用性的时间，并且研究了有关不良事件的流行病学研究的发表。
体外研究表明，未经佩戴的硅水凝胶隐形眼镜上细菌的黏附通常比羟乙基甲基丙烯酸酯基软镜上的细菌黏附数量更多。镜片佩戴对微生物黏附有不同的影响，这取决于所研究的镜片类型和微生物种类/属。任何类型的镜片都可能形成生物膜，这些生物膜可以保护细菌和真菌免受消毒剂的影响。真菌菌丝可以穿透大多数类型的镜片表面。棘阿米巴原虫黏附在第一代硅水凝胶镜片上的数量比第二代或羟乙基甲基丙烯酸酯基软镜上的数量更多。
微生物黏附于硅水凝胶隐形眼镜上，并与佩戴隐形眼镜期间产生的角膜浸润性病变有关。
