• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Blinded by the light: retinal phototoxicity in the context of safety studies.光致失明：安全性研究中的视网膜光毒性
Toxicol Pathol. 2013 Aug;41(6):813-25. doi: 10.1177/0192623312469308. Epub 2012 Dec 27.
2
Two spectral types of retinal light damage occur in albino as well as in pigmented rat: no essential role for melanin.白化大鼠和有色大鼠都会出现两种视网膜光损伤光谱类型：黑色素无重要作用。
Exp Eye Res. 1998 Feb;66(2):155-62. doi: 10.1006/exer.1997.0416.
3
Evidence against melanin as the mediator of retinal phototoxicity by short-wavelength light.反对黑色素作为短波长光致视网膜光毒性介质的证据。
Exp Eye Res. 1992 Jan;54(1):55-62. doi: 10.1016/0014-4835(92)90069-5.
4
Endoillumination during vitrectomy and phototoxicity thresholds.玻璃体切除术中的眼内照明及光毒性阈值。
Br J Ophthalmol. 2000 Dec;84(12):1372-5. doi: 10.1136/bjo.84.12.1372.
5
Illumination and phototoxicity issues in vitreoretinal surgery.玻璃体视网膜手术中的照明与光毒性问题。
Retina. 2008 Jan;28(1):1-4. doi: 10.1097/IAE.0b013e318156e015.
6
Phototoxic lesions induced by quinolone antibacterial agents in auricular skin and retina of albino mice.
Toxicol Pathol. 1993 Nov-Dec;21(6):554-61. doi: 10.1177/019262339302100606.
7
Retinal damage in pigmented and albino rats exposed to low levels of cyclic light following a single mydriatic treatment.单次散瞳治疗后暴露于低强度周期性光照下的有色和白化大鼠的视网膜损伤。
Curr Eye Res. 1985 Feb;4(2):97-102. doi: 10.3109/02713688508999974.
8
Long-term effects of light damage on the retina of albino and pigmented rats.光损伤对白化病大鼠和有色大鼠视网膜的长期影响。
Invest Ophthalmol Vis Sci. 2002 Mar;43(3):813-20.
9
Retinal phototoxicity.视网膜光毒性
Int Ophthalmol Clin. 1999 Spring;39(2):1-12. doi: 10.1097/00004397-199903920-00002.
10
Phototoxicity of herbal plants and herbal products.草药植物及草药产品的光毒性
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2013;31(3):213-55. doi: 10.1080/10590501.2013.824206.

引用本文的文献

1
Advances and therapeutic opportunities in visual cycle modulation.视觉循环调节的进展与治疗机遇
Prog Retin Eye Res. 2025 May;106:101360. doi: 10.1016/j.preteyeres.2025.101360. Epub 2025 Apr 23.
2
Accessible LED Lightbox for Light-induced Retinal Damage in Pigmented Mice.用于诱导色素沉着小鼠视网膜损伤的简易LED灯箱
Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):49. doi: 10.1167/iovs.66.2.49.
3
The LCHADD Mouse Model Recapitulates Early-Stage Chorioretinopathy in LCHADD Patients.LCHADD 小鼠模型再现 LCHADD 患者的早期脉络膜视网膜病变。
Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):33. doi: 10.1167/iovs.65.6.33.
4
Recommendations for measuring and standardizing light for laboratory mammals to improve welfare and reproducibility in animal research.关于测量和规范实验室哺乳动物光照以改善动物研究中的福利和可重复性的建议。
PLoS Biol. 2024 Mar 12;22(3):e3002535. doi: 10.1371/journal.pbio.3002535. eCollection 2024 Mar.
5
Sex-related differences in retinal function in Wistar rats: implications for toxicity and safety studies.Wistar大鼠视网膜功能的性别差异：对毒性和安全性研究的启示
Front Toxicol. 2023 May 23;5:1176665. doi: 10.3389/ftox.2023.1176665. eCollection 2023.
6
The Birth of the Mammalian Sleep.哺乳动物睡眠的起源
Biology (Basel). 2022 May 11;11(5):734. doi: 10.3390/biology11050734.
7
Effects of lighting environment on the degeneration of retinal ganglion cells in glutamate/aspartate transporter deficient mice, a mouse model of normal tension glaucoma.光照环境对谷氨酸/天冬氨酸转运体缺陷小鼠视网膜神经节细胞退变的影响，一种正常眼压性青光眼小鼠模型
Biochem Biophys Rep. 2022 Jan 5;29:101197. doi: 10.1016/j.bbrep.2021.101197. eCollection 2022 Mar.
8
Impact of Photoreceptor Loss on Retinal Circuitry.光感受器丧失对视网膜环路的影响。
Annu Rev Vis Sci. 2021 Sep 15;7:105-128. doi: 10.1146/annurev-vision-100119-124713.
9
Investigating Migraine-Like Behavior Using Light Aversion in Mice.使用避光法研究小鼠的偏头痛样行为。
J Vis Exp. 2021 Aug 11(174). doi: 10.3791/62839.
10
Experimental model to evaluate the benefits of lutein to prevent retinal phototoxicity during pars plana vitrectomy surgery using xenon source light illumination in rabbits.使用氙光源光照对兔子进行玻璃体切割手术时，评估叶黄素预防视网膜光毒性益处的实验模型。
Int J Retina Vitreous. 2019 May 7;5:11. doi: 10.1186/s40942-019-0161-3. eCollection 2019.

本文引用的文献

1
Retinal light damage: mechanisms and protection.视网膜光损伤：机制与保护。
Prog Retin Eye Res. 2010 Mar;29(2):113-34. doi: 10.1016/j.preteyeres.2009.11.004. Epub 2009 Dec 3.
2
Topography of retinal damage in light-exposed albino rats.光照白化大鼠视网膜损伤的地形图
Exp Eye Res. 2008 Sep;87(3):292-5. doi: 10.1016/j.exer.2008.06.002. Epub 2008 Jun 11.
3
Light-induced retinopathy: comparing adult and juvenile rats.光诱导视网膜病变：成年大鼠与幼年大鼠的比较
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3202-12. doi: 10.1167/iovs.05-1515.
4
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants.用于人类视网膜变性的睫状神经营养因子（CNTF）：通过封装细胞眼内植入物递送CNTF的I期试验。
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3896-901. doi: 10.1073/pnas.0600236103. Epub 2006 Feb 27.
5
Effect of visible light on normal and P23H-3 transgenic rat retinas: characterization of a novel retinoic acid derivative present in the P23H-3 retina.可见光对正常和P23H-3转基因大鼠视网膜的影响：P23H-3视网膜中一种新型视黄酸衍生物的特性
Photochem Photobiol. 2006 May-Jun;82(3):741-5. doi: 10.1562/2005-10-05-RA-712.
6
Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina.光照大鼠视网膜中4-羟基壬烯醛和4-羟基己烯醛对蛋白质的修饰作用
Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3859-68. doi: 10.1167/iovs.05-0672.
7
Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration.光诱导光感受器细胞凋亡及视网膜变性神经保护的分子机制
Prog Retin Eye Res. 2005 Mar;24(2):275-306. doi: 10.1016/j.preteyeres.2004.08.002. Epub 2004 Nov 11.
8
Rhodopsin phosphorylation in rats exposed to intense light.暴露于强光下的大鼠视紫红质磷酸化
Photochem Photobiol. 2005 May-Jun;81(3):541-7. doi: 10.1562/2004-08-27-RA-294.
9
Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.白化大鼠急性氨己烯酸视网膜毒性取决于光照而非γ-氨基丁酸。
Epilepsia. 2004 Sep;45(9):1043-8. doi: 10.1111/j.0013-9580.2004.01004.x.
10
New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant.携带光敏感RPE65亮氨酸变体的小鼠中的新型视网膜光损伤数量性状基因座。
Mamm Genome. 2004 Apr;15(4):277-83. doi: 10.1007/s00335-003-2336-2.

Blinded by the light: retinal phototoxicity in the context of safety studies.

作者信息

De Vera Mudry Maria Cristina, Kronenberg Sven, Komatsu Shun-ichiro, Aguirre Gustavo D

机构信息

Department of Non-Clinical Drug Safety, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

出版信息

Toxicol Pathol. 2013 Aug;41(6):813-25. doi: 10.1177/0192623312469308. Epub 2012 Dec 27.

DOI:10.1177/0192623312469308
PMID:23271306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3786130/
Abstract
摘要