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单次散瞳治疗后暴露于低强度周期性光照下的有色和白化大鼠的视网膜损伤。

Retinal damage in pigmented and albino rats exposed to low levels of cyclic light following a single mydriatic treatment.

作者信息

Williams R A, Howard A G, Williams T P

出版信息

Curr Eye Res. 1985 Feb;4(2):97-102. doi: 10.3109/02713688508999974.

DOI:10.3109/02713688508999974
PMID:3987351
Abstract

The present study demonstrated that less than three days of exposure to low levels of normally cycled ambient illumination are sufficient to cause death to photoreceptor cells in adult pigmented and albino rat. Cyclic light levels as low as 133 and 320 lux were found to destroy photoreceptor cells. A single mydriatic treatment with atropine immediately preceding the three-day exposure was sufficient to permit the effect in pigmented rats. No mydriasis was required for albino rats. When pigmented rats were reared in either 3 lux or 100 lux, it was found that these different light histories did not significantly affect the rats' subsequent susceptibility, during mydriasis, to retinal damage by cyclic illumination.

摘要

本研究表明,成年有色和白化大鼠暴露于低水平正常循环的环境光照不足三天,就足以导致光感受器细胞死亡。发现低至133勒克斯和320勒克斯的循环光照水平会破坏光感受器细胞。在为期三天的暴露之前立即用阿托品进行单次散瞳处理足以使有色大鼠产生这种效应。白化大鼠则无需散瞳。当有色大鼠在3勒克斯或100勒克斯的环境中饲养时,发现这些不同的光照经历并未显著影响大鼠在散瞳期间对循环光照造成视网膜损伤的后续易感性。

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