Lucas Robert J, Allen Annette E, Brainard George C, Brown Timothy M, Dauchy Robert T, Didikoglu Altug, Do Michael Tri H, Gaskill Brianna N, Hattar Samer, Hawkins Penny, Hut Roelof A, McDowell Richard J, Nelson Randy J, Prins Jan-Bas, Schmidt Tiffany M, Takahashi Joseph S, Verma Vandana, Voikar Vootele, Wells Sara, Peirson Stuart N
Centre for Biological Timing, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom.
Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.
PLoS Biol. 2024 Mar 12;22(3):e3002535. doi: 10.1371/journal.pbio.3002535. eCollection 2024 Mar.
Light enables vision and exerts widespread effects on physiology and behavior, including regulating circadian rhythms, sleep, hormone synthesis, affective state, and cognitive processes. Appropriate lighting in animal facilities may support welfare and ensure that animals enter experiments in an appropriate physiological and behavioral state. Furthermore, proper consideration of light during experimentation is important both when it is explicitly employed as an independent variable and as a general feature of the environment. This Consensus View discusses metrics to use for the quantification of light appropriate for nonhuman mammals and their application to improve animal welfare and the quality of animal research. It provides methods for measuring these metrics, practical guidance for their implementation in husbandry and experimentation, and quantitative guidance on appropriate light exposure for laboratory mammals. The guidance provided has the potential to improve data quality and contribute to reduction and refinement, helping to ensure more ethical animal use.
光使人能够看见，并对生理和行为产生广泛影响，包括调节昼夜节律、睡眠、激素合成、情感状态和认知过程。动物设施中的适当照明可促进动物福利，并确保动物在适当的生理和行为状态下进入实验。此外，在实验过程中，无论是将光明确用作自变量还是作为环境的一般特征，对光进行适当考虑都很重要。本共识观点讨论了用于量化适合非人类哺乳动物的光的指标，以及这些指标在改善动物福利和动物研究质量方面的应用。它提供了测量这些指标的方法、在饲养和实验中实施这些指标的实用指南，以及关于实验室哺乳动物适当光照暴露的定量指南。所提供的指南有可能提高数据质量，并有助于减少和优化实验，从而有助于确保更符合道德地使用动物。
