Department of Biotechnology, University of Sialkot, Sialkot 51310, Pakistan.
National Institute for Genomics and Advanced Biotechnology (NIGAB), National Agricultural Research Center, Islamabad 44100, Pakistan.
Molecules. 2022 Jul 4;27(13):4304. doi: 10.3390/molecules27134304.
Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional activities that aid in the prevention of infectious diseases in many mammalian bodies and promote tumor growth inhibition. Apigenin is a flavonoid with low toxicities and numerous bioactive properties due to which it has been considered as a traditional medicine for decades. Apigenin shows synergistic effects in combined treatment with sorafenib in the HepG2 human cell line (HCC) in less time and statistically reduces the viability of tumor cells, migration, gene expression and apoptosis. The combination of anti-cancerous drugs with apigenin has shown health promoting potential against various cancers. It can prevent cell mobility, maintain the cell cycle and stimulate the immune system. Apigenin also suppresses mTOR activity and raises the UVB-induced phagocytosis and reduces the cancerous cell proliferation and growth. It also has a high safety threshold, and active (anti-cancer) doses can be gained by consuming a vegetable and apigenin rich diet. Apigenin also boosted autophagosome formation, decreased cell proliferation and activated autophagy by preventing the activity of the PI3K pathway, specifically in HepG2 cells. This paper provides an updated overview of apigenin's beneficial anti-inflammatory, antibacterial, antiviral, and anticancer effects, making it a step in the right direction for therapeutics. This study also critically analyzed the effect of apigenin on cancer cell signaling pathways including the PI3K/AKT/MTOR, JAK/STAT, NF-κB and ERK/MAPK pathways.
植物生物活性化合物，特别是芹菜素，具有治疗潜力和功能活性，有助于预防许多哺乳动物体内的传染病，并促进肿瘤生长抑制。芹菜素是一种具有低毒性和多种生物活性特性的类黄酮，因此几十年来一直被认为是一种传统药物。芹菜素在与索拉非尼联合治疗 HepG2 人肝癌细胞系（HCC）时表现出协同作用，在更短的时间内显著降低肿瘤细胞活力、迁移、基因表达和细胞凋亡。抗癌药物与芹菜素联合使用已显示出对各种癌症具有促进健康的潜力。它可以防止细胞迁移，维持细胞周期并刺激免疫系统。芹菜素还抑制 mTOR 活性，提高 UVB 诱导的吞噬作用，降低癌细胞增殖和生长。它还具有很高的安全阈值，通过食用富含蔬菜和芹菜素的饮食可以获得有效（抗癌）剂量。芹菜素还通过抑制 PI3K 通路的活性，特别是在 HepG2 细胞中，促进自噬体形成、减少细胞增殖并激活自噬。本文提供了关于芹菜素有益的抗炎、抗菌、抗病毒和抗癌作用的最新概述，为治疗学迈出了正确的一步。本研究还批判性地分析了芹菜素对包括 PI3K/AKT/mTOR、JAK/STAT、NF-κB 和 ERK/MAPK 通路在内的癌细胞信号通路的影响。
