HealthPartners Institute for Education and Research, Minneapolis, MN, USA.
Prev Med. 2013 Mar;56(3-4):171-7. doi: 10.1016/j.ypmed.2012.12.014. Epub 2012 Dec 28.
The Keep It Off trial evaluated the efficacy of a phone-based weight loss maintenance intervention among adults who had recently lost weight in Minnesota (2007-2010).
419 adults who had recently lost ≥ 10% of their body weight were randomized to the "Guided" or "Self-Directed" intervention. Guided participants received a 10 session workbook, 10 biweekly, eight monthly and six bimonthly phone coaching calls, bimonthly weight graphs and tailored letters based on self-reported weights. Self-Directed participants received the workbook and two calls. Primary outcomes are weight change and maintenance (regain of <2.5% of baseline body weight).
Mixed model repeated-measures analysis examining weight change revealed a significant time by treatment group interaction (p<0.0085). Guided participants regained significantly less weight than the Self-Directed participants at 12 and 24 months. The odds of 24 month maintenance were 1.37 (95% CI: 0.97-2.03) times greater in the Guided than in the Self-Directed group. When maintenance rates were compared across all follow-ups, there was a consistently higher maintenance rate for Guided participants (HR 1.31, 95% CI: 1.12-1.54).
A sustained, supportive phone- and mail-based intervention promotes weight loss maintenance relative to a brief intervention for participants who have recently lost weight.
Keep It Off 试验评估了基于电话的减肥维持干预措施在明尼苏达州（2007-2010 年）近期减肥的成年人中的疗效。
419 名近期体重减轻≥10%的成年人被随机分为“指导”或“自我指导”干预组。指导组参与者接受了 10 次会话的工作簿、10 次双周、8 次每月和 6 次双月电话辅导电话、双月体重图表和根据自我报告的体重定制的信件。自我指导组参与者接受了工作簿和两次电话。主要结局是体重变化和维持（恢复体重<基线体重的 2.5%）。
混合模型重复测量分析检查体重变化显示，治疗组之间存在显著的时间与治疗组之间的相互作用（p<0.0085）。指导组参与者在 12 个月和 24 个月时体重恢复明显少于自我指导组。与自我指导组相比，指导组在 24 个月时维持的可能性高 1.37 倍（95%CI：0.97-2.03）。当比较所有随访的维持率时，指导组的维持率始终较高（HR 1.31，95%CI：1.12-1.54）。
与近期减肥的参与者进行的简短干预相比，持续的、支持性的电话和邮件干预可以促进减肥维持。
