简明综述：干细胞生成培养的红细胞。
Concise review: production of cultured red blood cells from stem cells.
机构信息
Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, New York, NY, USA.
出版信息
Stem Cells Transl Med. 2012 Dec;1(12):927-33. doi: 10.5966/sctm.2012-0097. Epub 2012 Nov 26.
Abstract
In the Western world, the volunteer-based collection system covers most transfusion needs, but transient shortages regularly develop and blood supplies are vulnerable to potentially major disruptions. The production of cultured red blood cells from stem cells is slowly emerging as a potential alternative. The various cell sources, the niche applications most likely to reach the clinic first, and some of the remaining technical issues are reviewed here.
摘要
在西方世界，基于志愿者的采集系统满足了大部分输血需求，但定期会出现短暂的短缺，并且血液供应容易受到潜在的重大干扰。从干细胞中培养红细胞正在缓慢成为一种潜在的替代方法。本文综述了各种细胞来源、最有可能首先进入临床应用的特定领域，以及一些尚存的技术问题。
相似文献
1
Concise review: production of cultured red blood cells from stem cells.简明综述：干细胞生成培养的红细胞。
Stem Cells Transl Med. 2012 Dec;1(12):927-33. doi: 10.5966/sctm.2012-0097. Epub 2012 Nov 26.
2
Generation of red blood cells from human embryonic/induced pluripotent stem cells for blood transfusion.从人类胚胎/诱导多能干细胞生成红细胞用于输血。
Int J Hematol. 2012 Jun;95(6):610-6. doi: 10.1007/s12185-012-1107-9. Epub 2012 May 31.
3
From stem cells to red blood cells: how far away from the clinical application?从干细胞到红细胞：离临床应用还有多远？
Sci China Life Sci. 2014 Jun;57(6):581-5. doi: 10.1007/s11427-014-4667-5. Epub 2014 May 15.
4
Concise review: stem cell-derived erythrocytes as upcoming players in blood transfusion.简明综述：干细胞来源的红细胞作为即将出现的输血领域的参与者。
Stem Cells. 2012 Aug;30(8):1587-96. doi: 10.1002/stem.1136.
5
The red blood cell storage lesion: the end of the beginning.红细胞储存损伤：开端的结束。
Transfusion. 2016 Jun;56(6):1462-8. doi: 10.1111/trf.13609. Epub 2016 Apr 15.
6
In vitro production of red blood cells.红细胞的体外生成。
Transfus Apher Sci. 2011 Aug;45(1):85-9. doi: 10.1016/j.transci.2011.06.007. Epub 2011 Jul 1.
7
Progresses in overcoming the limitations of in vitro erythropoiesis using human induced pluripotent stem cells.在利用人诱导多能干细胞克服体外红细胞生成的局限性方面的进展。
Stem Cell Res Ther. 2024 May 15;15(1):142. doi: 10.1186/s13287-024-03754-9.
8
Concise review: stem cell-based approaches to red blood cell production for transfusion.简明综述：基于干细胞的输血用红细胞生成方法。
Stem Cells Transl Med. 2014 Mar;3(3):346-55. doi: 10.5966/sctm.2013-0054. Epub 2013 Dec 20.
9
In vitro generation of red blood cells for transfusion: a model for regenerative medicine.用于输血的红细胞的体外生成：再生医学模型。
Regen Med. 2012 Jan;7(1):1-2. doi: 10.2217/rme.11.108.
10
In vitro production of transfusable red blood cells.体外生产可输血的红细胞。
Biotechnol Genet Eng Rev. 2008;25:187-201. doi: 10.5661/bger-25-187.
引用本文的文献
1
Progresses in overcoming the limitations of in vitro erythropoiesis using human induced pluripotent stem cells.在利用人诱导多能干细胞克服体外红细胞生成的局限性方面的进展。
Stem Cell Res Ther. 2024 May 15;15(1):142. doi: 10.1186/s13287-024-03754-9.
2
Current status of red blood cell manufacturing in 3D culture and bioreactors.3D培养和生物反应器中红细胞制造的现状
Blood Res. 2023 Apr 30;58(S1):S46-S51. doi: 10.5045/br.2023.2023008. Epub 2023 Apr 7.
3
Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases.溶酶体铁循环在小鼠巨噬细胞中依赖于 LcytB 和 Steap3 还原酶。
Blood Adv. 2022 Mar 22;6(6):1692-1707. doi: 10.1182/bloodadvances.2021005609.
4
Comprehensive phenotyping of erythropoiesis in human bone marrow: Evaluation of normal and ineffective erythropoiesis.全面表型分析人类骨髓中的红细胞生成：评估正常和无效的红细胞生成。
Am J Hematol. 2021 Sep 1;96(9):1064-1076. doi: 10.1002/ajh.26247. Epub 2021 Jun 3.
5
Depleted iron stores in voluntary blood donors: A three-center cross-sectional study in Ghana.自愿献血者铁储备耗竭：加纳的一项三中心横断面研究。
Asian J Transfus Sci. 2020 Jul-Dec;14(2):149-157. doi: 10.4103/ajts.AJTS_112_18. Epub 2020 Dec 19.
6
BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells.BMI1 可使来自人外周血单个核细胞的功能性成红细胞大量扩增。
Mol Ther. 2021 May 5;29(5):1918-1932. doi: 10.1016/j.ymthe.2021.01.022. Epub 2021 Jan 21.
7
Differentiation of human induced pluripotent stem cells into erythroid cells.人诱导多能干细胞向红细胞的分化。
Stem Cell Res Ther. 2020 Nov 16;11(1):483. doi: 10.1186/s13287-020-01998-9.
8
In Vitro Generation of Red Blood Cells from Stem Cell and Targeted Therapy.体外从干细胞和靶向治疗生成红细胞。
Cell Transplant. 2020 Jan-Dec;29:963689720946658. doi: 10.1177/0963689720946658.
9
Dexamethasone Predisposes Human Erythroblasts Toward Impaired Lipid Metabolism and Renders Their Expansion Highly Dependent on Plasma Lipoproteins.地塞米松使人类成红细胞易于出现脂质代谢受损，并使其扩增高度依赖血浆脂蛋白。
Front Physiol. 2019 Apr 4;10:281. doi: 10.3389/fphys.2019.00281. eCollection 2019.
10
Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy.骨髓干细胞用于清除循环中的HIV：一种假设的治疗策略。
J Biol Res (Thessalon). 2018 Feb 5;25:3. doi: 10.1186/s40709-018-0075-5. eCollection 2018 Dec.
本文引用的文献
1
Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood.从人类胚胎干细胞、卵黄囊、胎肝、脐血和外周血中分离的 CD34 阳性细胞产生新型高产红细胞的方法。
Stem Cells Transl Med. 2012 Aug;1(8):604-14. doi: 10.5966/sctm.2012-0059. Epub 2012 Aug 2.
2
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.红系/髓系祖细胞和造血干细胞来源于内皮细胞的不同群体。
Cell Stem Cell. 2011 Dec 2;9(6):541-52. doi: 10.1016/j.stem.2011.10.003.
3
Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells.从人诱导多能干细胞中产生胚胎和胎儿样红细胞。
PLoS One. 2011;6(10):e25761. doi: 10.1371/journal.pone.0025761. Epub 2011 Oct 13.
4
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications.从干细胞到红细胞：多种蛋白质、RNA 和染色质修饰在多个层面上调节红细胞生成。
Blood. 2011 Dec 8;118(24):6258-68. doi: 10.1182/blood-2011-07-356006. Epub 2011 Oct 12.
5
Compartmental hollow fiber capillary membrane-based bioreactor technology for in vitro studies on red blood cell lineage direction of hematopoietic stem cells.基于隔室中空纤维毛细管膜的生物反应器技术在体外研究造血干细胞红细胞谱系方向上的应用。
Tissue Eng Part C Methods. 2012 Feb;18(2):133-42. doi: 10.1089/ten.TEC.2011.0305. Epub 2011 Dec 28.
6
Proof of principle for transfusion of in vitro-generated red blood cells.体外生成红细胞输注的原理验证。
Blood. 2011 Nov 10;118(19):5071-9. doi: 10.1182/blood-2011-06-362038. Epub 2011 Sep 1.
7
Allogeneic cord blood red cells for transfusion.用于输血的异基因脐血红细胞。
Transfus Med Rev. 2012 Jan;26(1):90-1; author reply 91-2. doi: 10.1016/j.tmrv.2011.06.002. Epub 2011 Aug 9.
8
Under HEMA conditions, self-replication of human erythroblasts is limited by autophagic death.在 HEMA 条件下，人红细胞的自我复制受到自噬性死亡的限制。
Blood Cells Mol Dis. 2011 Oct 15;47(3):182-97. doi: 10.1016/j.bcmd.2011.06.001. Epub 2011 Jul 20.
9
Ultra-high-yield manufacture of red blood cells from hematopoietic stem cells.从造血干细胞中超高产量制造红细胞。
Tissue Eng Part C Methods. 2011 Nov;17(11):1131-7. doi: 10.1089/ten.TEC.2011.0207. Epub 2011 Sep 8.
10
Induced pluripotent stem cells: opportunities and challenges.诱导多能干细胞：机遇与挑战。
Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2198-207. doi: 10.1098/rstb.2011.0016.
Zotero 插件