Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, New York, NY, USA.
Stem Cells Transl Med. 2012 Dec;1(12):927-33. doi: 10.5966/sctm.2012-0097. Epub 2012 Nov 26.
In the Western world, the volunteer-based collection system covers most transfusion needs, but transient shortages regularly develop and blood supplies are vulnerable to potentially major disruptions. The production of cultured red blood cells from stem cells is slowly emerging as a potential alternative. The various cell sources, the niche applications most likely to reach the clinic first, and some of the remaining technical issues are reviewed here.
在西方世界，基于志愿者的采集系统满足了大部分输血需求，但定期会出现短暂的短缺，并且血液供应容易受到潜在的重大干扰。从干细胞中培养红细胞正在缓慢成为一种潜在的替代方法。本文综述了各种细胞来源、最有可能首先进入临床应用的特定领域，以及一些尚存的技术问题。
