Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI 02912, United States.
Drug Alcohol Depend. 2013 Jul 1;131(1-2):171-4. doi: 10.1016/j.drugalcdep.2012.12.016. Epub 2013 Jan 9.
Although marijuana is the most commonly used illicit substance in the US, only a small portion of users go on to develop dependence, suggesting that there are substantial individual differences in vulnerability to marijuana-related problems among users. Deficits in working memory and high trait impulsivity are two factors that may place marijuana users at increased risk for experiencing related problems.
Using baseline data from an experimental study that recruited 104 frequent marijuana users (M=71.86% of prior 60 days, SD=22%), we examined the associations of working memory and trait impulsivity with marijuana-related problems.
Lower working memory, as measured by Trail Making Test B, but not short-term memory capacity, predicted more marijuana-related problems. Higher trait impulsivity scores were independently associated with greater number of problems.
Results suggest that marijuana users with reduced executive cognitive ability are more susceptible to developing problems related to their use. Trait impulsivity and executive working memory appear to be independent risk factors for experiencing marijuana-related problems.
尽管大麻是美国最常用的非法物质，但只有一小部分使用者会发展成依赖，这表明在使用者中，对与大麻相关问题的易感性存在很大的个体差异。工作记忆缺陷和高特质冲动性是使大麻使用者面临更高风险的两个因素，可能会经历相关问题。
使用一项实验研究的基线数据，该研究招募了 104 名经常使用大麻的人（M=71.86%的过去 60 天，SD=22%），我们研究了工作记忆和特质冲动性与大麻相关问题之间的关联。
Trail Making Test B 测量的工作记忆能力较低，但短期记忆能力不受影响，与更多的大麻相关问题相关。更高的特质冲动性得分与更多的问题独立相关。
结果表明，执行认知能力较低的大麻使用者更容易出现与使用相关的问题。特质冲动性和执行工作记忆似乎是经历大麻相关问题的独立风险因素。
