Harlow Center for Biological Psychology, University of Wisconsin, Madison, WI 53715, United States.
Res Vet Sci. 2013 Jun;94(3):549-54. doi: 10.1016/j.rvsc.2012.11.017. Epub 2013 Jan 10.
The realization that pregnant and infant monkeys were challenged by high nutritional needs for iron led vendors to markedly increase iron concentrations in commercial diets. Yet, no systematic research was conducted to investigate the consequences of this important dietary change. Hematology and iron panels were determined for 142 infant rhesus monkeys gestated and reared on 3 different diets varying in iron concentration (180, 225 or 380 mg Fe/kg). Anemia was significantly more prevalent in offspring from females fed the 180 and 225 mg Fe/kg diets (32-41% versus 0 for the 380 mg Fe/kg diet, P<0.001). Higher hepcidin levels were protective against iron overload in infants from the 380 mg Fe/kg condition. These findings indicate a highly fortified diet during pregnancy continues to have postnatal benefits for the growing infant. However, for those interested in iron deficiency, lower iron diets provide a reliable way to generate anemic infant monkeys for research.
研究发现，怀孕和婴儿猴子对铁的营养需求很高，这促使供应商大幅提高商业饮食中的铁浓度。然而，没有人进行系统的研究来调查这种重要饮食变化的后果。对 142 只在三种不同铁浓度（180、225 或 380mgFe/kg）的饮食中孕育和饲养的恒河猴婴儿进行了血液学和铁谱分析。在喂食 180 和 225mgFe/kg 饮食的雌性后代中，贫血的发生率明显更高（32-41%，而 380mgFe/kg 饮食中为 0，P<0.001）。在来自 380mgFe/kg 条件的婴儿中，较高的铁调素水平对铁过载具有保护作用。这些发现表明，在怀孕期间强化饮食对正在成长的婴儿仍有产后益处。然而，对于那些对缺铁感兴趣的人来说，较低铁的饮食为产生贫血的猴子婴儿提供了一种可靠的研究方法。
