微小 RNA 在 B 细胞发育和功能中的作用。
The role of microRNAs in B-cell development and function.
机构信息
Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
出版信息
Cell Mol Immunol. 2013 Mar;10(2):107-12. doi: 10.1038/cmi.2012.62. Epub 2013 Jan 14.
Abstract
MicroRNA (miRNA)-mediated gene silencing at the translational level has led to novel discoveries for numerous biological processes. Recently, there has been increasing evidence to indicate that miRNAs are involved in normal immune functions and inflammation. In this review, we focus on recent advances that have elucidated the role of miRNAs in B-cell development, differentiation, apoptosis and function. While the regulatory mechanisms of miRNAs in controlling and maintaining B-cell fate remain largely uncharacterized, further studies on miRNAs and their targets will increase our understanding of B-cell development and function. Such studies may be able to provide new therapeutic strategies for treating autoimmune diseases.
摘要
微小 RNA（miRNA）介导的翻译水平基因沉默为许多生物过程的研究带来了新的发现。最近有越来越多的证据表明 miRNA 参与了正常的免疫功能和炎症反应。在这篇综述中，我们重点介绍了 miRNA 在 B 细胞发育、分化、凋亡和功能中的作用的最新研究进展。尽管 miRNA 控制和维持 B 细胞命运的调节机制在很大程度上仍未被阐明，但对 miRNA 及其靶标的进一步研究将增进我们对 B 细胞发育和功能的理解。这些研究可能为治疗自身免疫性疾病提供新的治疗策略。
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