Le Hong-Gam T, Tang Maolong, Ridges Ryan, Huang David, Jacobs Deborah S
Boston Foundation for Sight, 464 Hillside Avenue, Suite 205, Needham, MA 02494, USA.
J Ophthalmol. 2012;2012:812034. doi: 10.1155/2012/812034. Epub 2012 Dec 18.
Purpose. To assess optical coherence tomography (OCT) for guiding design and fit of a prosthetic device for corneal disease. Methods. A prototype time domain OCT scanner was used to image the anterior segment of patients fitted with large diameter (18.5-20 mm) prosthetic devices for corneal disease. OCT images were processed and analyzed to characterize corneal diameter, corneal sagittal height, scleral sagittal height, scleral toricity, and alignment of device. Within-subject variance of OCT-measured parameters was evaluated. OCT-measured parameters were compared with device parameters for each eye fitted. OCT image correspondence with ocular alignment and clinical fit was assessed. Results. Six eyes in 5 patients were studied. OCT measurement of corneal diameter (coefficient of variation, CV = 0.76%), cornea sagittal height (CV = 2.06%), and scleral sagittal height (CV = 3.39%) is highly repeatable within each subject. OCT image-derived measurements reveal strong correlation between corneal sagittal height and device corneal height (r = 0.975) and modest correlation between scleral and on-eye device toricity (r = 0.581). Qualitative assessment of a fitted device on OCT montages reveals correspondence with slit lamp images and clinical assessment of fit. Conclusions. OCT imaging of the anterior segment is suitable for custom design and fit of large diameter (18.5-20 mm) prosthetic devices used in the treatment of corneal disease.
目的。评估光学相干断层扫描（OCT）在指导角膜疾病假体装置设计和适配方面的作用。方法。使用一台原型时域OCT扫描仪对佩戴用于角膜疾病的大直径（18.5 - 20毫米）假体装置的患者眼前节进行成像。对OCT图像进行处理和分析，以确定角膜直径、角膜矢高、巩膜矢高、巩膜曲率以及装置的对齐情况。评估OCT测量参数的受试者内方差。将OCT测量参数与每只佩戴装置眼睛的装置参数进行比较。评估OCT图像与眼部对齐和临床适配情况的对应性。结果。对5名患者的6只眼睛进行了研究。OCT测量角膜直径（变异系数，CV = 0.76%）、角膜矢高（CV = 2.06%）和巩膜矢高（CV = 3.39%）在每个受试者内具有高度可重复性。OCT图像衍生测量显示角膜矢高与装置角膜高度之间有很强的相关性（r = 0.975），巩膜与眼上装置曲率之间有适度相关性（r = 0.581）。在OCT蒙片上对适配装置进行定性评估，显示与裂隙灯图像以及适配的临床评估结果相符。结论。眼前节的OCT成像适用于定制设计和适配用于治疗角膜疾病的大直径（18.5 - 20毫米）假体装置。
