Haghighat S, Akbari M E, Ghaffari S, Yavari P
Epidemiology Department, School of Public Health, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
Asian Pac J Cancer Prev. 2012;13(11):5525-8. doi: 10.7314/apjcp.2012.13.11.5525.
Breast cancer is the most common cancer in women. Improvements of early diagnosis modalities have led to longer survival rates. This study aimed to determine the 5, 10 and 15 year mortality rates of breast cancer patients compared to the normal female population.
The follow up data of a cohort of 615 breast cancer patients referred to Iranian Breast Cancer Research Center (BCRC) from 1986 to 1996 was considered as reference breast cancer dataset. The dataset was divided into 5 year age groups and the 5, 10 and 15 year probability of death for each group was estimated. The annual mortality rate of Iranian women was obtained from the Death Registry system. Standardized mortality ratios (SMRs) of breast cancer patients were calculated using the ratio of the mortality rate in breast cancer patients over the general female population.
The mean age of breast cancer patients at diagnosis time was 45.9 (±10.5) years ranging from 24-74. A total of 73, 32 and 2 deaths were recorded at 5, 10 and 15 years, respectively, after diagnosis. The SMRs for breast cancer patients at 5, 10 and 15 year intervals after diagnosis were 6.74 (95% CI, 5.5- 8.2), 6.55 (95%CI, 5-8.1) and 1.26 (95%CI, 0.65-2.9), respectively.
Results showed that the observed mortality rate of breast cancer patients after 15 years from diagnosis was very similar to expected rates in general female population. This finding would be useful for clinicians and health policy makers to adopt a beneficial strategy to improve breast cancer survival. Further follow-up time with larger sample size and a pooled analysis of survival rates of different centres may shed more light on mortality patterns of breast cancer.
乳腺癌是女性最常见的癌症。早期诊断方式的改进使得生存率提高。本研究旨在确定与正常女性人群相比，乳腺癌患者的5年、10年和15年死亡率。
将1986年至1996年转诊至伊朗乳腺癌研究中心（BCRC）的615名乳腺癌患者的随访数据视为参考乳腺癌数据集。该数据集按5岁年龄组划分，并估计每组的5年、10年和15年死亡概率。伊朗女性的年死亡率从死亡登记系统获取。使用乳腺癌患者死亡率与一般女性人群死亡率之比计算乳腺癌患者的标准化死亡率（SMR）。
乳腺癌患者诊断时的平均年龄为45.9（±10.5）岁，范围为24 - 74岁。诊断后5年、10年和15年分别记录到73例、32例和2例死亡。诊断后5年、10年和15年间隔的乳腺癌患者SMR分别为6.74（95%CI，5.5 - 8.2）、6.55（95%CI，5 - 8.1）和1.26（95%CI，0.65 - 2.9）。
结果显示，乳腺癌患者诊断后15年的观察死亡率与一般女性人群的预期死亡率非常相似。这一发现对临床医生和卫生政策制定者采用有益策略提高乳腺癌生存率将是有用的。进一步延长随访时间、增加样本量以及对不同中心的生存率进行汇总分析可能会更清楚地揭示乳腺癌的死亡模式。
