Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Antimicrob Agents Chemother. 2013 Apr;57(4):1921-5. doi: 10.1128/AAC.00007-13. Epub 2013 Jan 14.
Biofilm formation by Pseudomonas aeruginosa has been implicated in the pathology of chronic wounds. Both the d and l isoforms of tryptophan inhibited P. aeruginosa biofilm formation on tissue culture plates, with an equimolar ratio of d and l isoforms producing the greatest inhibitory effect. Addition of d-/l-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation by P. aeruginosa.
铜绿假单胞菌的生物膜形成与慢性创面的病理学有关。色氨酸的 d 和 l 两种异构体均能抑制组织培养板上铜绿假单胞菌的生物膜形成，等摩尔浓度的 d 和 l 异构体产生最大的抑制效果。将 d-/l-色氨酸添加到现有的生物膜中可抑制进一步的生物膜生长并导致部分生物膜解体。色氨酸显著增加了铜绿假单胞菌的泳动性，这可能部分解释了其生物膜形成减少的原因。
