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丙泊酚输注导致尿液变绿：一例报告

Green Urine Discoloration due to Propofol Infusion: A Case Report.

作者信息

Shioya Nobuki, Ishibe Yoriko, Shibata Shigehiro, Makabe Hideyuki, Kan Shigenori, Matsumoto Naoya, Takahashi Gaku, Yamada Yasuhiko, Endo Shigeatsu

机构信息

Department of Critical Care and Emergency, Iwate Prefectural Advanced Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan.

出版信息

Case Rep Emerg Med. 2011;2011:242514. doi: 10.1155/2011/242514. Epub 2011 Dec 27.

DOI:10.1155/2011/242514
PMID:23326690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3542914/
Abstract

We present a 19-year-old man who excreted green urine after propofol infusion. The patient was admitted to our hospital for injuries sustained in a traffic accident and underwent surgery. After starting continuous infusion of propofol for postoperative sedation, his urine became dark green. Serum total bilirubin and urine bilirubin were both elevated. We believe that the green discoloration of the urine was caused by propofol infusion and was related to impaired enterohepatic circulation and extrahepatic glucuronidation in the kidneys.

摘要

我们报告一名19岁男性，在输注丙泊酚后排出绿色尿液。该患者因交通事故受伤入院并接受了手术。在开始持续输注丙泊酚进行术后镇静后，他的尿液变成深绿色。血清总胆红素和尿胆红素均升高。我们认为尿液的绿色变色是由丙泊酚输注引起的，并且与肝肠循环受损和肾脏肝外葡萄糖醛酸化有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/3542914/1ff0fe6e0832/CRIM.EM2011-242514.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/3542914/0ac893931d54/CRIM.EM2011-242514.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/3542914/1ff0fe6e0832/CRIM.EM2011-242514.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/3542914/0ac893931d54/CRIM.EM2011-242514.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb56/3542914/1ff0fe6e0832/CRIM.EM2011-242514.002.jpg

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Propofol-Induced Green Urine in a Patient with Refractory Status Epilepticus.

本文引用的文献

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Obstructive jaundice, bilirubin and propofol pharmacodynamics.
Acta Anaesthesiol Scand. 2010 Oct;54(9):1152; author reply 1152. doi: 10.1111/j.1399-6576.2010.02260.x.
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Does bilirubin change the free concentration of propofol?
Acta Anaesthesiol Scand. 2010 May;54(5):653-4. doi: 10.1111/j.1399-6576.2009.02172.x.
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Green urine.绿色尿液。
Lancet. 2009 Apr 25;373(9673):1462. doi: 10.1016/S0140-6736(09)60309-3.
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异丙酚致难治性癫痫持续状态患者出现绿色尿液
J Epilepsy Res. 2018 Dec 31;8(2):97-99. doi: 10.14581/jer.18017. eCollection 2018 Dec.
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Propofol-Induced Green Breast Milk: A Case Report.丙泊酚导致的绿色母乳：一例报告
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Pink Urine Syndrome: A Combination of Insulin Resistance and Propofol.粉红色尿综合征：胰岛素抵抗与丙泊酚的联合作用
Kidney Int Rep. 2018 Oct 13;4(1):30-39. doi: 10.1016/j.ekir.2018.10.009. eCollection 2019 Jan.
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Clinical Pharmacokinetics and Pharmacodynamics of Propofol.丙泊酚的临床药代动力学和药效学。
Clin Pharmacokinet. 2018 Dec;57(12):1539-1558. doi: 10.1007/s40262-018-0672-3.
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Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects.丙泊酚和福泊酚的代谢谱：临床和法医解释方面。
Biomed Res Int. 2018 May 24;2018:6852857. doi: 10.1155/2018/6852857. eCollection 2018.
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Analgosedation of adult patients with elevated intracranial pressure : Survey of current clinical practice in Austria.颅内压升高的成年患者的镇痛镇静：奥地利当前临床实践调查
Wien Klin Wochenschr. 2018 Jan;130(1-2):45-53. doi: 10.1007/s00508-017-1228-5. Epub 2017 Jul 21.
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Green Urine in Traditional Persian Medicine: Differential Diagnosis and Clinical Relevance.传统波斯医学中的绿色尿液：鉴别诊断与临床意义
J Evid Based Complementary Altern Med. 2017 Apr;22(2):232-236. doi: 10.1177/2156587216641828. Epub 2016 Jul 8.
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Green Urine Due to Propofol: A Case Report with Review of Literature.丙泊酚导致的绿色尿液：一例病例报告并文献复习
J Clin Diagn Res. 2015 Nov;9(11):OD03-4. doi: 10.7860/JCDR/2015/15681.6706. Epub 2015 Nov 1.
Effects of propofol analogs on glucuronidation of propofol, an anesthetic drug, by human liver microsomes.
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Propofol-related green urine.丙泊酚相关的绿色尿液。
Kidney Int. 2008 Oct;74(7):978. doi: 10.1038/ki.2008.139.
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A case of green urine after ingestion of herbicides.一例摄入除草剂后出现绿色尿液的病例。
Korean J Intern Med. 2008 Mar;23(1):42-4. doi: 10.3904/kjim.2008.23.1.42.
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Medications and green urine.药物与绿色尿液。
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Green urine after intragastric balloon placement for the treatment of morbid obesity.胃内气球置入治疗病态肥胖后出现绿色尿液。
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