Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Am J Public Health. 2013 Sep;103(9):1656-65. doi: 10.2105/AJPH.2012.300911. Epub 2013 Jan 17.
We examined the association between regular cigarette smoking and new onset of mood and anxiety disorders.
We used logistic regression analysis to detect associations between regular smoking and new-onset disorders during the 3-year follow-up among 34 653 participants in the longitudinal US National Epidemiologic Survey on Alcohol and Related Conditions (2001-2005). We used instrumental variable methods to assess the appropriateness of these models.
Regular smoking was associated with an increased risk of new onset of mood and anxiety disorders in multivariable analyses (Fdf = 5,61 = 11.73; P < .001). Participants who smoked a larger number of cigarettes daily displayed a trend toward greater likelihood of new-onset disorders. Age moderated the association of smoking with most new-onset disorders. The association was mostly statistically significant and generally stronger in participants aged 18 to 49 years but was smaller and mostly nonsignificant in older adults.
Our finding of a stronger association between regular cigarette smoking and increased risk of new-onset mood and anxiety disorders among younger adults suggest the need for vigorous antismoking campaigns and policy initiatives targeting this age group.
我们研究了经常吸烟与心境和焦虑障碍新发之间的关系。
我们使用逻辑回归分析，在 34653 名参加美国纵向国家酒精和相关条件流行病学调查（2001-2005 年）的参与者中，检测了在 3 年随访期间经常吸烟与新发障碍之间的关联。我们使用工具变量方法评估了这些模型的适宜性。
在多变量分析中，经常吸烟与心境和焦虑障碍新发的风险增加有关（Fdf = 5,61 = 11.73；P <.001）。每天吸烟数量较多的参与者出现新发障碍的可能性呈上升趋势。年龄调节了吸烟与大多数新发障碍之间的关系。这种关联在 18 至 49 岁的参与者中大多数具有统计学意义，且通常更强，但在年龄较大的成年人中，这种关联较小，且大多不显著。
我们发现经常吸烟与年轻成年人中新发心境和焦虑障碍风险增加之间的关联更强，这表明需要针对这一年龄组开展强有力的反吸烟运动和政策举措。
