Department of Trauma & Orthopedics, Peking University People's Hospital, Beijing, China.
Int J Med Sci. 2013;10(2):171-5. doi: 10.7150/ijms.5312. Epub 2013 Jan 5.
Nerve regeneration and re-innervation are usually difficult after peripheral nerve injury. Epineurium neurorrhaphy to recover the nerve continuity is the traditional choice of peripheral nerve mutilation without nerve defects, whereas the functional recovery remains quite unsatisfactory. Based on previous research in SD rats and Rhesus Monkeys, a multiple centers clinical trial about biodegradable conduit small gap tubulization for peripheral nerve mutilation to substitute traditional epineurial neurorrhaphy was carried out. Herein, the authors reviewed the literature that focused on peripheral nerve injury and possible clinical application, and confirmed the clinical possibilities of biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation. The biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation may be a revolutionary innovation in peripheral nerve injury and repair field.
周围神经损伤后，神经再生和再支配通常较为困难。在没有神经缺损的情况下，修复神经连续性的神经外膜缝合是外周神经损伤的传统选择，但其功能恢复仍不尽如人意。基于 SD 大鼠和恒河猴的前期研究，一项关于可生物降解导管小间隙套接术治疗周围神经损伤的多中心临床试验已替代传统的神经外膜缝合术。本文作者回顾了周围神经损伤及可能的临床应用相关文献，证实了可生物降解导管小间隙套接术替代传统神经外膜缝合术治疗周围神经损伤的临床可能性。可生物降解导管小间隙套接术替代传统神经外膜缝合术治疗周围神经损伤可能是周围神经损伤和修复领域的一项革命性创新。
