Hamley Ian W, Castelletto Valeria
Department of Chemistry, University of Reading , Whiteknights, Reading, RG6 6AD, United Kingdom.
Bioconjug Chem. 2017 Mar 15;28(3):731-739. doi: 10.1021/acs.bioconjchem.6b00284. Epub 2016 Jul 11.
This Topical Review briefly discusses selected highlights of recent research on self-assembling peptide amphiphiles (PAs) and polymer-peptide conjugates. Subjects covered include new polymer chemistries used to prepare polymer-peptide conjugates, PA self-assembly landscapes and kinetics, developments in the application of bioactive PAs and the relationship between self-assembly and bioactivity, novel PA/biopolymer composites, functional π-stacking peptide conjugates, use of enzymes to tune self-assembly, and developments in high throughput methods and the design and application of sequenced peptides.
本专题综述简要讨论了近期关于自组装肽两亲分子（PAs）和聚合物-肽共轭物研究的部分亮点。涵盖的主题包括用于制备聚合物-肽共轭物的新型聚合物化学、PA自组装态势和动力学、生物活性PA应用的进展以及自组装与生物活性之间的关系、新型PA/生物聚合物复合材料、功能性π-堆积肽共轭物、利用酶调节自组装，以及高通量方法的进展和序列肽的设计与应用。
