Newcomer J W, Faustman W O, Yeh W, Csernansky J G
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA.
Psychiatry Res. 1990 Mar;31(3):243-50. doi: 10.1016/0165-1781(90)90093-k.
Depression can occur in schizophrenia but can be difficult to distinguish from negative symptoms of the illness. To evaluate whether concurrent use of the Hamilton Rating Scale for Depression (HRSD) and the Brief Psychiatric Rating Scale (BPRS) could successfully separate depression and negative symptoms, we examined ratings on 69 unmedicated schizophrenic inpatients. A classical BPRS depression subscale score correlated highly (rho = 0.80) with the HRSD total score. The classical BPRS "negative symptom" subscale score was unrelated to both the BPRS and HRSD depression summary measures. Among individual HRSD items, negative symptoms correlated only with work/activities and retardation. The findings suggest that negative and depressive symptoms may be assessed independently.
抑郁症可发生于精神分裂症患者中，但可能难以与该疾病的阴性症状相区分。为评估同时使用汉密尔顿抑郁评定量表（HRSD）和简明精神病评定量表（BPRS）是否能成功区分抑郁症状和阴性症状，我们对69名未接受药物治疗的精神分裂症住院患者的评定结果进行了检查。经典的BPRS抑郁分量表得分与HRSD总分高度相关（rho = 0.80）。经典的BPRS“阴性症状”分量表得分与BPRS和HRSD的抑郁总结指标均无关联。在HRSD的各个项目中，阴性症状仅与工作/活动及迟缓相关。研究结果表明，阴性症状和抑郁症状可能可独立评估。
