Harvey P D, Docherty N M, Serper M R, Rasmussen M
Dept. of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029.
Schizophr Bull. 1990;16(1):147-56. doi: 10.1093/schbul/16.1.147.
Schizophrenic (n = 21) and manic (n = 19) patients were followed up an average of 8 months after an index assessment during an acute admission. These patients were tested at both assessments with laboratory tasks measuring distractibility and reality monitoring and were examined with clinical ratings of positive and negative thought disorder. For manic patients, none of the measures predicted the patients' clinical state of followup, while negative thought disorder, although rare, was temporally stable. For the schizophrenic patients, both negative thought disorder and distractibility were temporally stable, and more severe negative thought disorder was found at index assessment in patients who were psychotic at followup. The differential utility of laboratory and clinical indices for the prediction of overall clinical state is related to these data.
对21名精神分裂症患者和19名躁狂症患者在急性入院期间进行首次评估后平均随访8个月。在两次评估中，这些患者都接受了测量注意力分散和现实监测的实验室任务测试，并接受了关于阳性和阴性思维障碍的临床评定。对于躁狂症患者，没有一项测量指标能够预测患者的随访临床状态，而阴性思维障碍虽然罕见，但具有时间稳定性。对于精神分裂症患者，阴性思维障碍和注意力分散都具有时间稳定性，并且在随访时出现精神病性症状的患者在首次评估时发现有更严重的阴性思维障碍。实验室指标和临床指标在预测总体临床状态方面的不同效用与这些数据有关。
