Endocrinology Chair, 6th Medical Sciences Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 3-5 Louis Pasteur, Cluj-Napoca, 400349, Romania.
J Ovarian Res. 2013 Jan 22;6(1):4. doi: 10.1186/1757-2215-6-4.
Under-carboxylated osteocalcin (ucOC), the precursor substrate of bone biomarker OC is a potent regulator of energy metabolism by promoting insulin production and adiponectin synthesis and decreasing fat stores. The aim of the present study was to point out the potential role of ucOC in the physiopathology of polycystic ovary syndrome (PCOS), a common disorder defined by the constellation of anovulation, insulinresistance, hyperinsulinemia, obesity and androgen excess.
In this prospective case-control investigation, 78 young premenopausal women, i.e. 52 PCOS patients and 26 age- and body mass index (BMI)-matched healthy controls, were successively enrolled. Recruitment of PCOS patients was performed according to Androgen Excess-Polycystic Ovary Syndrome (AE-PCOS) Society 2006 criteria. All study participants were subjected to clinical examination, whole-body composition assessment and measurements of serum ucOC, OC (1-49), glucose and lipids, insulin, total testosterone (TT), estradiol, sex-hormone binding globulin (SHBG), high-sensitivity C-reactive protein (Hs-CRP) and β-CrossLaps.
BMI-stratified multivariate analysis revealed significantly higher ucOC levels in PCOS vs. controls in lean (p = 0.001) but not overweight and obese study participants (p = 0.456). Notably, a positive correlation between ucOC and TT (p = 0.018), calculated free testosterone (cFT, p = 0.028) and serum insulin (p = 0.036), respectively, was found to be confined to the lean analysis subgroup. Furthermore, in stepwise multiple regression models, β-CrossLaps and cFT were able to predict 46.71% of serum ucOC variability. (1-43/49)OC failed to be significantly associated to any PCOS trait.
Circulating ucOC concentration is related to key endocrine PCOS characteristics in a weight-dependent manner. Within the bone-pancreas loop, high ucOC may favor insulin release in lean hyperandrogenic women to compensate for impaired insulin sensitivity.
非羧化骨钙素（ucOC）是骨生物标志物 OC 的前体底物，它通过促进胰岛素的产生和脂联素的合成，减少脂肪储存，是能量代谢的有力调节剂。本研究旨在指出 ucOC 在多囊卵巢综合征（PCOS）发病机制中的潜在作用，PCOS 是一种常见的疾病，其特征是排卵障碍、胰岛素抵抗、高胰岛素血症、肥胖和雄激素过多。
在这项前瞻性病例对照研究中，连续纳入 78 名年轻绝经前妇女，即 52 名 PCOS 患者和 26 名年龄和体重指数（BMI）匹配的健康对照者。PCOS 患者的招募是根据雄激素过多-多囊卵巢综合征（AE-PCOS）学会 2006 年的标准进行的。所有研究参与者均接受了临床检查、全身成分评估以及血清 ucOC、OC（1-49）、葡萄糖和脂质、胰岛素、总睾酮（TT）、雌二醇、性激素结合球蛋白（SHBG）、高敏 C 反应蛋白（Hs-CRP）和β-胶原特殊序列的测定。
BMI 分层多变量分析显示，在瘦体质（p=0.001）而非超重和肥胖的研究参与者中，PCOS 患者的 ucOC 水平显著升高（p=0.456）。值得注意的是，ucOC 与 TT（p=0.018）、计算游离睾酮（cFT，p=0.028）和血清胰岛素（p=0.036）之间的正相关关系仅局限于瘦体质亚组。此外，在逐步多元回归模型中，β-CrossLaps 和 cFT 能够预测 46.71%的血清 ucOC 变异性。（1-43/49）OC 与任何 PCOS 特征均无显著相关性。
循环 ucOC 浓度与以体重依赖的方式与关键的内分泌 PCOS 特征相关。在骨-胰腺循环中，高 ucOC 可能有利于瘦高雄性激素女性胰岛素的释放，以代偿胰岛素敏感性的降低。
