Bossers Willem J R, van der Woude Lucas H V, Boersma Froukje, Scherder Erik J A, van Heuvelen Marieke J G
Center for Human Movement Sciences, Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):589-609. doi: 10.1159/000345038. Epub 2012 Dec 8.
AIM/GOAL: To recommend a set of neuropsychological and physical exercise tests for researchers to assess cognition and physical fitness in clinical trials with older patients with dementia; to create consensus, decrease heterogeneity, and improve research quality.
A literature search (2005-2011) yielded 89 randomized controlled trials. To provide information on test recommendations the frequency of test use, effect size of the test outcome, study quality, and psychometric properties of tests were analyzed.
Fifty-nine neuropsychological tests (cognitive domains: global cognition, executive functioning, memory, and attention) and 10 exercise tests (physical domains: endurance capacity, muscle strength, balance, and mobility) were found.
The Severe Impairment Battery, Mini Mental State Examination, and Alzheimer Disease Assessment Scale - cognitive subscale were recommended to measure global cognition. The Verbal Fluency Test Category/Letters, Clock Drawing Test, and Trail Making Test-B were recommended to measure executive functioning. No specific memory test could be recommended. The Digit Span Forward, Digit Span Backward, and Trail Making Test-A were recommended to measure attention. As physical exercise tests, the Timed Up and Go and Six Meter Walk for mobility, the Six Minute Walk Distance for endurance capacity, and the Tinetti Balance Scale were recommended.
目的：推荐一组神经心理学和体育锻炼测试，供研究人员在针对老年痴呆患者的临床试验中评估认知能力和身体健康状况；达成共识，减少异质性，提高研究质量。
文献检索（2005 - 2011年）得到89项随机对照试验。为提供测试推荐信息，分析了测试使用频率、测试结果的效应大小、研究质量和测试的心理测量特性。
发现了59项神经心理学测试（认知领域：整体认知、执行功能、记忆和注意力）和10项锻炼测试（身体领域：耐力、肌肉力量、平衡和活动能力）。
推荐严重损伤成套测验、简易精神状态检查表和阿尔茨海默病评估量表 - 认知分量表来测量整体认知。推荐言语流畅性测试类别/字母、画钟测验和连线测验B来测量执行功能。无法推荐特定的记忆测试。推荐数字广度顺背、数字广度倒背和连线测验A来测量注意力。作为体育锻炼测试，推荐定时起立行走测试和6米步行测试来评估活动能力，6分钟步行距离测试来评估耐力，以及Tinetti平衡量表来评估平衡能力。
