Division of Gastroenterology, University of Missouri, Columbia, MO 65201, United States.
World J Gastroenterol. 2013 Jan 14;19(2):155-7. doi: 10.3748/wjg.v19.i2.155.
Bowel preparation prior to colonoscopy is essential to maximize the benefits of colonoscopy. Numerous bowel preparations have been studied, ranging from 4 L polyethylene glycol (PEG) to split-dose regimens to 2 L PEG with an adjunct laxative (senna, bisacodyl, ascorbic acid). Due to the large volume of PEG required for adequate bowel preparation, many studies have focused on reducing this large volume to only 2 L PEG with the addition of an adjunct. Recently, a randomized controlled trial by Tajika et al showed that the addition of mosapride to only 1.5 L PEG was non-inferior to mosapride and 2 L PEG for bowel cleansing but did provide improvements in patient tolerance. This study offers yet another potential bowel preparation for patients undergoing colonoscopy and may trigger further studies with 1.5 L PEG with an adjunct. In this letter, we discuss the current state of bowel preparation prior to colonoscopy and offer information to guide clinicians on choosing the appropriate bowel preparation for their patients.
在结肠镜检查前进行肠道准备对于最大限度地提高结肠镜检查的益处至关重要。已经研究了许多肠道准备方法，范围从 4 升聚乙二醇（PEG）到分剂量方案，再到 2 升 PEG 加辅助泻药（番泻叶、比沙可啶、抗坏血酸）。由于 PEG 所需的大量体积用于充分的肠道准备，许多研究都集中在将这个大量体积减少到只有 2 升 PEG，并加入辅助药物。最近，Tajika 等人进行的一项随机对照试验表明，仅在 1.5 升 PEG 中添加莫沙必利与莫沙必利和 2 升 PEG 相比，在肠道清洁方面没有差异，但确实提高了患者的耐受性。这项研究为接受结肠镜检查的患者提供了另一种潜在的肠道准备方法，可能会引发进一步研究，以确定在 1.5 升 PEG 中加入辅助药物的效果。在这封信中，我们讨论了结肠镜检查前肠道准备的现状，并提供信息，以指导临床医生为患者选择适当的肠道准备方法。
