将光反应性神经节苷脂GM1给予培养中的人成纤维细胞后，胞质神经节苷脂 - 蛋白质复合物的形成。
Formation of a cytosolic ganglioside-protein complex following administration of photoreactive ganglioside GM1 to human fibroblasts in culture.
作者信息
Chigorno V, Valsecchi M, Acquotti D, Sonnino S, Tettamanti G
机构信息
Department of Medical Chemistry and Biochemistry, Medical School, University of Milan, Italy.
出版信息
FEBS Lett. 1990 Apr 24;263(2):329-31. doi: 10.1016/0014-5793(90)81406-e.
PMID:2335236
Abstract
A GM 1 ganglioside derivative bearing a photoreactive nitrophenyl azide group and tritium labeled at the acetyl group of N-acetylneuraminic acid, has been administered to cultured human fibroblasts. With photolabeling experiments we found that a portion of the ganglioside in the cell cytosol was associated with a soluble protein of about 30 kDa.
摘要
一种带有光反应性硝基苯基叠氮基团且在N-乙酰神经氨酸的乙酰基处标记有氚的GM1神经节苷脂衍生物，已被施用于培养的人成纤维细胞。通过光标记实验，我们发现细胞胞质溶胶中的一部分神经节苷脂与一种约30 kDa的可溶性蛋白质相关联。
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