Farrow D C, Davis S
University of New Mexico Medical Center, New Mexico Tumor Registry, Albuquerque 87131.
Int J Cancer. 1990 May 15;45(5):816-20. doi: 10.1002/ijc.2910450504.
A population-based case-control study was conducted to examine the relationship between certain medical conditions, the use of tobacco, alcohol and coffee, and the incidence of pancreatic cancer. Cases (N = 148) were married men ages 20 through 74 years diagnosed with pancreatic cancer from July 1982 through June 1986. Controls (N = 188) were identified by random digit dialing. Wives, responding as surrogates for both cases and controls, were interviewed by telephone and completed, alone, a food frequency questionnaire. The risk of pancreatic cancer was increased in individuals with a history of diabetes or pancreatitis, and decreased in those with a history of tonsillectomy. Individuals who had ever smoked cigarettes were at elevated risk of disease. This excess risk was confined to current smokers, in whom the odds ratio was 3.2 (95% CI 1.8-5.7); the risk among former smokers resembled that in those who had never smoked. There was no excess risk of pancreatic cancer among those who had ever used other forms of tobacco, including pipe tobacco, cigars and chewing tobacco. After adjustment for demographic and dietary characteristics, there was no association between pancreatic cancer risk and the intake of coffee, beer, red wine, hard liquor or all alcohol combined; a slight reduction in risk was seen among those consuming white wine daily.
开展了一项基于人群的病例对照研究，以调查某些疾病状况、烟草、酒精和咖啡的使用与胰腺癌发病率之间的关系。病例（N = 148）为1982年7月至1986年6月期间确诊为胰腺癌的20至74岁已婚男性。对照（N = 188）通过随机数字拨号确定。作为病例和对照的替代者，妻子们通过电话接受了访谈，并独自完成了一份食物频率问卷。有糖尿病或胰腺炎病史的个体患胰腺癌的风险增加，而有扁桃体切除病史的个体患胰腺癌的风险降低。曾经吸烟的个体患疾病的风险升高。这种额外风险仅限于当前吸烟者，其比值比为3.2（95%可信区间1.8 - 5.7）；既往吸烟者的风险与从未吸烟者相似。曾经使用过其他形式烟草（包括烟斗烟草、雪茄和嚼烟）的个体患胰腺癌没有额外风险。在对人口统计学和饮食特征进行调整后，胰腺癌风险与咖啡、啤酒、红酒、烈性酒或所有酒精摄入总量之间没有关联；每天饮用白葡萄酒的个体风险略有降低。
