Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Campus Universitario, 7000 Tandil, Argentina.
Vet Parasitol. 2013 May 1;194(1):70-4. doi: 10.1016/j.vetpar.2013.01.003. Epub 2013 Jan 12.
The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n=12 each), respectively. Each experiment involved two different groups (n=6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic(®), Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp.
本实验的目的是评估阿苯达唑（OFZ）作为单一口服剂量（30mg/kg）对自然感染有猪蛔虫、食道口线虫、后圆线虫和猪鞭虫的猪的临床疗效。36 头本地生态型仔猪分为三个独立的实验，分别命名为 I、II 和 III（每组 12 头）。每个实验涉及两个不同的组（每组 6 头）：未处理的对照组和 OFZ 处理组。动物自然感染猪蛔虫（实验 I、II 和 III）、食道口线虫（实验 I 和 II）、猪鞭虫（实验 II 和 III）和后圆线虫（实验 I）。处理组动物口服给予 OFZ（Synanthic®，梅里亚有限公司，9.06%混悬液），剂量为 30mg/kg。在治疗后 5 天，动物被处死，并按照目前可用的 WAAVP 指南对控制疗效试验确定 OFZ 治疗的临床疗效。本实验中没有动物在研究过程中出现任何不良反应。单次口服 30mg/kg 的 OFZ 治疗对三个实验中存在的所有线虫寄生虫均显示出 100%的疗效。总之，在当前的实验条件下，口服给予自然感染的仔猪单次剂量 30mg/kg 的 OFZ 是安全且高度有效的（100%），可治疗猪蛔虫、食道口线虫、猪鞭虫和后圆线虫的成虫阶段。
