金黄色葡萄球菌生物膜促进抗生素耐药性的水平转移。
Staphylococcus aureus biofilms promote horizontal transfer of antibiotic resistance.
机构信息
Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2013 Apr;57(4):1968-70. doi: 10.1128/AAC.02008-12. Epub 2013 Jan 28.
Abstract
Growth as a biofilm facilitates the emergence of antibiotic resistance by mutation in Staphylococcus aureus. Here we demonstrate that biofilm growth of this species also dramatically increases horizontal transfer of plasmid-borne antibiotic resistance determinants by conjugation/mobilization and that standard laboratory practices to induce conjugation in staphylococci achieve optimal efficiency owing to the presence of a biofilm.
摘要
生物膜的生长促进了金黄色葡萄球菌突变引起的抗生素耐药性的出现。在这里，我们证明了这种物种的生物膜生长也极大地增加了通过接合/转移的质粒携带抗生素抗性决定因素的水平转移，并且由于生物膜的存在，标准的实验室诱导葡萄球菌接合的实践可以达到最佳效率。
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