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Biological characterization of human monoclonal antibodies to rabies virus.

作者信息

Dietzschold B, Gore M, Casali P, Ueki Y, Rupprecht C E, Notkins A L, Koprowski H

机构信息

Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104-4268.

出版信息

J Virol. 1990 Jun;64(6):3087-90. doi: 10.1128/JVI.64.6.3087-3090.1990.

DOI:10.1128/JVI.64.6.3087-3090.1990
PMID:2335829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC249498/
Abstract

Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized by this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392f/249498/9ca28db07357/jvirol00061-0649-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392f/249498/9ca28db07357/jvirol00061-0649-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/392f/249498/9ca28db07357/jvirol00061-0649-a.jpg

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本文引用的文献

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Antigenic analysis of rabies and Mokola virus from Zimbabwe using monoclonal antibodies.使用单克隆抗体对来自津巴布韦的狂犬病病毒和莫科拉病毒进行抗原分析。
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Genomic Surveillance of Rabies Virus in Georgian Canines.格鲁吉亚犬类狂犬病病毒的基因组监测
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Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses.未修饰的狂犬病 mRNA 疫苗可引发高交叉中和抗体滴度和多样化的 B 细胞记忆应答。
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A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis.一种人源单克隆抗体鸡尾酒可广泛中和北美的狂犬病病毒变异株，有望成为狂犬病暴露后预防的候选药物。
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Emerg Microbes Infect. 2019;8(1):1584-1592. doi: 10.1080/22221751.2019.1683436.
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NPJ Vaccines. 2017 Jul 10;2:19. doi: 10.1038/s41541-017-0019-3. eCollection 2017.
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Structural basis of antibody function.抗体功能的结构基础。
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Investigation of the antigenic structure of rabies virus glycoprotein by monoclonal antibodies.用单克隆抗体研究狂犬病病毒糖蛋白的抗原结构。
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Effective protection of monkeys against death from street virus by post-exposure administration of tissue-culture rabies vaccine.暴露后接种组织培养狂犬病疫苗可有效保护猴子免于死于街头病毒。
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Rabies group-specific ribonucleoprotein antigen and a test system for grouping and typing of rhabdoviruses.狂犬病属特异性核糖核蛋白抗原及一种用于弹状病毒分组和分型的检测系统。
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