Wan Yuqing, Borsic Andrea, Hartov Alex, Halter Ryan
Thayer School of Engineering, Dartmouth College, Hanover, NH 03766, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6220-3. doi: 10.1109/EMBC.2012.6347415.
Previous studies have shown that prostate cancer may be detected by a combined transrectal ultrasound and electrical impedance tomography imaging system. However, the sensitivity of the imaging system is limited due to very little current established in the far field distant from the probe surface. Consequently, biopsy needles are introduced to the imaging system to provide current paths in the distal regions. This study demonstrates that image sensitivity can be improved by incorporating the needle electrodes. A phantom experiment is presented to show that contrast to the background is enhanced by 17.4% when imaging with needle electrodes. Simulated reconstructions and some preliminary clinical data also suggest the sensitivity improvement. In summary, TREIT with needle electrodes in the tissue may have great potential in future clinical prostate cancer detection.
先前的研究表明,经直肠超声和电阻抗断层成像系统相结合可检测出前列腺癌。然而,由于在远离探头表面的远场中建立的电流非常小,成像系统的灵敏度受到限制。因此,将活检针引入成像系统以在远端区域提供电流路径。本研究表明,通过加入针电极可以提高图像灵敏度。进行了一项模型实验,结果表明使用针电极成像时与背景的对比度提高了17.4%。模拟重建和一些初步临床数据也表明了灵敏度的提高。总之,在组织中使用针电极的经直肠电阻抗断层成像在未来临床前列腺癌检测中可能具有巨大潜力。